Synonyms: compound 14b [PMID: 37616488]
Compound class:
Synthetic organic
Comment: This compound acts as a dual VEGFR/PARP inhibitor [1]. It is proposed to simultaneously generate an anti-angiogenic effect and induce synthetic lethality in susceptible tumours. Compound 14b has good oral bioavailability, and is active in in vitro and in vivo models.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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References |
1. Li Y, Liu Y, Zhang D, Chen J, Yang G, Tang P, Yang C, Liu J, Zhang J, Ouyang L. (2023)
Discovery, Synthesis, and Evaluation of Novel Dual Inhibitors of a Vascular Endothelial Growth Factor Receptor and Poly(ADP-Ribose) Polymerase for BRCA Wild-Type Breast Cancer Therapy. J Med Chem, 66 (17): 12069-12100. [PMID:37616488] |