bulevirtide   Click here for help

GtoPdb Ligand ID: 12775

Synonyms: BLV | formerly Myrcludex B | Hepcludex®
Approved drug
bulevirtide is an approved drug (EMA (2020), UK HMRA (2021))
Comment: Bulevirtide is a lipopeptide antiviral agent. It blocks entry of the hepatitis-causing viruses HBV and HDV into hepatocytes [1]. The peptide structure of bulevirtide is derived from the pre-S1 domain of the large envelope protein of HBV surface antigen (HBsAg) [4], that binds to the heoatocyte expressed surface protein sodium/bile acid and sulphated solute cotransporter 1 (NTCP; SLC10A1) to mediate viral entry into host cells. Bulevirtide functionally blocks this entry process [3].
Classification Click here for help
Compound class Peptide or derivative
Approved drug? Yes (EMA (2020), UK HMRA (2021))
International Nonproprietary Names Click here for help
INN number INN
10692 bulevirtide
Synonyms Click here for help
BLV | formerly Myrcludex B | Hepcludex®
Database Links Click here for help
GtoPdb PubChem SID 483123323
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