Synonyms: Example 1 [WO2018127184A1]
Compound class:
Synthetic organic
Comment: This is the chemical structure for the INN ficonalkib. It is one of the compounds that are claimed as anaplastic lymphoma kinase (ALK) inhibitors in patent WO2018127184A1 [1]. Potency data within the patent indicates that ficonalkib (example 1) inhibits wild-type ALK and several ALK mutants, and is more potent than the reference inhibitor crizotinib in vitro. Ficonalkib (example 1) can cross the blood-brain barrier.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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References |
1. Liu G, Jiao N, Wang S, Min W, Liu X, Sun Y, Zhang H. (2018)
Anaplastic lymphoma kinase inhibitor and preparation method and use thereof. Patent number: WO2018127184A1. Assignee: Beijing Sailintai Pharmaceutical Technology Co., Ltd.. Priority date: 06/01/2017. Publication date: 12/07/2018. |