SMTP-7   Click here for help

GtoPdb Ligand ID: 12300

Synonyms: Stachybotrys microspora triprenyl phenol 7 | BIIB131 | SMTP7 | TMS-007
Compound class: Natural product
Comment: SMTP-7 is a natural triprenyl phenol that's produced by Stachybotrys microspora (a fungus) [2]. It is a complex molecule with 5 chiral centers whose absolute stereochemical configuration has been determined using microcrystal electron diffraction (MicroED) [7]. Total chemical synthesis has been reported [3]. SMTP-7 produces thrombolytic [5], anti-inflammatory, and antioxidant effects. It is being considered as a clinical anti-thrombotic agent for use in stroke patients [6]. The compound has activity as a plasminogen modulator and soluble epoxide hydrolase inhibitor that may offer a novel therapeutic intervention for cardiometabolic diseases [1].
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 12
Hydrogen bond donors 5
Rotatable bonds 18
Topological polar surface area 177.3
Molecular weight 869.09
XLogP 7.25
No. Lipinski's rules broken 4

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES CC(=CCC/C(=C/CC[C@]1(C)[C@H](CC2=C(C3=C(C=C2O)C(=O)N(CCC[C@@H](C(=O)O)N4CC5=C(C=C(C6=C5O[C@](C)(CC/C=C(\C)/CCC=C(C)C)[C@H](C6)O)O)C4=O)C3)O1)O)/C)C
Isomeric SMILES C/C(=C\CC[C@@]1([C@H](CC=2C(=C3CN(C(C3=CC2O)=O)[C@H](C(=O)O)CCCN4C(C5=CC(=C6C(=C5C4)O[C@@]([C@H](C6)O)(CC/C=C(/CCC=C(C)C)\C)C)O)=O)O1)O)C)/CCC=C(C)C
InChI InChI=1S/C51H68N2O10/c1-30(2)14-9-16-32(5)18-11-21-50(7)43(56)26-36-41(54)24-34-38(45(36)62-50)28-52(47(34)58)23-13-20-40(49(60)61)53-29-39-35(48(53)59)25-42(55)37-27-44(57)51(8,63-46(37)39)22-12-19-33(6)17-10-15-31(3)4/h14-15,18-19,24-25,40,43-44,54-57H,9-13,16-17,20-23,26-29H2,1-8H3,(H,60,61)/b32-18+,33-19+/t40-,43-,44-,50+,51+/m0/s1
InChI Key CRNDCHORWGDFGR-RUESYUOVSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
References
1. Bellien J, Djerada Z. (2022)
Use of inhibitors of phosphatase activity of soluble epoxide for the treatment of cardiometabolic diseases.
Patent number: US20220023265A1. Assignee: Universitaire De Reims. Priority date: 16/09/2019. Publication date: 27/01/2022.
2. Hasumi K, Yamamichi S, Harada T. (2010)
Small-molecule modulators of zymogen activation in the fibrinolytic and coagulation systems.
FEBS J, 277 (18): 3675-87. [PMID:20718867]
3. Kwok DA, Huang R, Shang D, Xue Y, Walker DG. (2024)
Total Synthesis of Stachybotrys microspora Triprenol Phenol-7 (SMTP-7).
Org Lett, 26 (3): 697-701. [PMID:38232331]
4. Moritoyo T, Nishimura N, Hasegawa K, Ishii S, Kirihara K, Takata M, Svensson AK, Umeda-Kameyama Y, Kawarasaki S, Ihara R et al.. (2023)
A first-in-human study of the anti-inflammatory profibrinolytic TMS-007, an SMTP family triprenyl phenol.
Br J Clin Pharmacol, 89 (6): 1809-1819. [PMID:36562925]
5. Sawada H, Nishimura N, Suzuki E, Zhuang J, Hasegawa K, Takamatsu H, Honda K, Hasumi K. (2014)
SMTP-7, a novel small-molecule thrombolytic for ischemic stroke: a study in rodents and primates.
J Cereb Blood Flow Metab, 34 (2): 235-41. [PMID:24192639]
6. Suzuki E, Nishimura N, Yoshikawa T, Kunikiyo Y, Hasegawa K, Hasumi K. (2018)
Efficacy of SMTP-7, a small-molecule anti-inflammatory thrombolytic, in embolic stroke in monkeys.
Pharmacol Res Perspect, 6 (6): e00448. [PMID:30546909]
7. Wang B, Lin Y. (2022)
Absolute configuration determination of SMTP-7 via microcrystal electron diffraction (MicroED).
Chem Commun (Camb), 58 (94): 13071-13074. [PMID:36305866]