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YTK-2205   Click here for help

GtoPdb Ligand ID: 12281

Synonyms: example 2 [US20210163399A1] | YTK 2205 | YTK2205
Compound class: Synthetic organic
Comment: YTK-2205's chemical structure is claimed in patents as a sequestosome 1 (p62) agonist that may be useful for prevention or management of proteinopathies [2].
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 2
Hydrogen bond donors 2
Rotatable bonds 12
Topological polar surface area 50.72
Molecular weight 391.21
XLogP 4.12
No. Lipinski's rules broken 1

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES OCCNCc1ccc(c(c1)OCCc1ccccc1)OCCc1ccccc1
Isomeric SMILES OCCNCc1ccc(OCCc2ccccc2)c(OCCc2ccccc2)c1
InChI InChI=1S/C25H29NO3/c27-16-15-26-20-23-11-12-24(28-17-13-21-7-3-1-4-8-21)25(19-23)29-18-14-22-9-5-2-6-10-22/h1-12,19,26-27H,13-18,20H2
InChI Key RQNGRJHGRKZOEL-UHFFFAOYSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Bioactivity Comments
YTK-2205 has been used to establish the protective role of p62-dependent autophagy in paracetamol-induced liver injury in vivo [1].
Selectivity at other protein targets
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
sequestosome 1 Hs Agonist Activation - - - 2
⤷ [2]
Description: Determined as increased oligomerisation of p62 (and reduction in p62 momoner) in response to treatment with test compound, by immunoblotting. Or increased formation of intracellular puncta (autophagosomes) containing p26 or misfolded huntingtin protein in cultured cells by confocal microscopy.