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loracarbef   Click here for help

GtoPdb Ligand ID: 12247

Synonyms: KT-3777 | Lorabid® | LY163892
Approved drug
loracarbef is an approved drug (FDA (1991))
Compound class: Synthetic organic
Comment: Loracarbef is a second generation cephalosporin, belonging to the β-lactam class of antibacterial compounds.
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 7
Hydrogen bond donors 3
Rotatable bonds 5
Topological polar surface area 112.73
Molecular weight 349.08
XLogP -1.69
No. Lipinski's rules broken 0

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES N[C@H](c1ccccc1)C(=O)N[C@H]1[C@H]2CCC(=C(N2C1=O)C(=O)O)Cl
Isomeric SMILES C1CC(=C(N2[C@H]1[C@@H](C2=O)NC(=O)[C@@H](c1ccccc1)N)C(=O)O)Cl
InChI InChI=1S/C16H16ClN3O4/c17-9-6-7-10-12(15(22)20(10)13(9)16(23)24)19-14(21)11(18)8-4-2-1-3-5-8/h1-5,10-12H,6-7,18H2,(H,19,21)(H,23,24)/t10-,11-,12+/m1/s1
InChI Key JAPHQRWPEGVNBT-UTUOFQBUSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes. US FDA (1991)
IUPAC Name Click here for help
(6R,7S)-7-[(2R)-2-amino-2-phenylacetamido]-3-chloro-8-oxo-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
International Nonproprietary Names Click here for help
INN number INN
6360 loracarbef
Synonyms Click here for help
KT-3777 | Lorabid® | LY163892
Database Links Click here for help
Specialist databases
Antibiotic DB Antibiotic DB Database logo Loracarbef
Other databases
CAS Registry No. 76470-66-1 (source: Scifinder)
ChEBI CHEBI:47544
ChEMBL Ligand CHEMBL1013
DrugBank Ligand DB00447
DrugCentral Ligand 1603
GtoPdb PubChem SID 473153835
PubChem CID 5284585
Search Google for chemical match using the InChIKey JAPHQRWPEGVNBT-UTUOFQBUSA-N
Search Google for chemicals with the same backbone JAPHQRWPEGVNBT
Search PubMed clinical trials loracarbef
Search PubMed titles loracarbef
Search PubMed titles/abstracts loracarbef
UniChem Compound Search for chemical match using the InChIKey JAPHQRWPEGVNBT-UTUOFQBUSA-N
UniChem Connectivity Search for chemical match using the InChIKey JAPHQRWPEGVNBT-UTUOFQBUSA-N
Wikipedia Loracarbef