sibeprenlimab   Click here for help

GtoPdb Ligand ID: 12102

Synonyms: VIS-649 | VIS649
Immunopharmacology Ligand
Compound class: Antibody
Comment: Sibeprenlimab (VIS-649) is a fully humanized IgG2κ monoclonal antibody that targets the B-cell growth factor APRIL (TNFSF13) [1,4]. The antibody binds with high affinity to human trimeric APRIL, and potently blocks APRIL binding to its receptors TACI (transmembrane activator and CAML interactor) and BCMA (B-cell maturation antigen). It was developed by Visterra for anti-inflammatory potential.
Classification Click here for help
Compound class Antibody
International Nonproprietary Names Click here for help
INN number INN
11575 sibeprenlimab
Synonyms Click here for help
VIS-649 | VIS649
Database Links Click here for help
Specialist databases
IMGT/mAb-DB 1144
Other databases
GtoPdb PubChem SID 472319224
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