revaprazan   Click here for help

GtoPdb Ligand ID: 12007

Synonyms: Revanex® | YH-1885 | YH1885
Approved drug
revaprazan is an approved drug (S Korea (2007))
Compound class: Synthetic organic
Comment: Revaprazan (YH-1885) is a K+-competitive acid blocker (P-CAB)/proton pump inhibitor [1-2]. First in human data demonstrating the on-target effect of revaprazan were reported in 2010 [3].
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Click here for structure editor
Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 3
Topological polar surface area 41.05
Molecular weight 362.19
XLogP 5.51
No. Lipinski's rules broken 1

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES Fc1ccc(cc1)Nc1nc(c(c(n1)C)C)N1CCc2c(C1C)cccc2
Isomeric SMILES CC1c2ccccc2CCN1c1nc(nc(c1C)C)Nc1ccc(cc1)F
InChI InChI=1S/C22H23FN4/c1-14-15(2)24-22(25-19-10-8-18(23)9-11-19)26-21(14)27-13-12-17-6-4-5-7-20(17)16(27)3/h4-11,16H,12-13H2,1-3H3,(H,24,25,26)
InChI Key LECZXZOBEZITCL-UHFFFAOYSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
References
1. Han KS, Choi HC, Yoo JK, Lee JW, Lee MG. (1997)
Determination of a new proton pump inhibitor, YH1885, in human plasma and urine by high-performance liquid chromatography.
J Chromatogr B Biomed Sci Appl, 696 (2): 312-6. [PMID:9323554]
2. Han KS, Kim YG, Yoo JK, Lee JW, Lee MG. (1998)
Pharmacokinetics of a new reversible proton pump inhibitor, YH1885, after intravenous and oral administrations to rats and dogs: hepatic first-pass effect in rats.
Biopharm Drug Dispos, 19 (8): 493-500. [PMID:9840211]
3. Kim HK, Park SH, Cheung DY, Cho YS, Kim JI, Kim SS, Chae HS, Kim JK, Chung IS. (2010)
Clinical trial: inhibitory effect of revaprazan on gastric acid secretion in healthy male subjects.
J Gastroenterol Hepatol, 25 (10): 1618-25. [PMID:20880169]
4. Tanaka S, Morita M, Yamagishi T, Madapally HV, Hayashida K, Khandelia H, Gerle C, Shigematsu H, Oshima A, Abe K. (2022)
Structural Basis for Binding of Potassium-Competitive Acid Blockers to the Gastric Proton Pump.
J Med Chem, 65 (11): 7843-7853. [PMID:35604136]
5. Yoon YA, Park CS, Cha MH, Choi H, Sim JY, Kim JG. (2010)
Novel pyrimidines as acid pump antagonists (APAs).
Bioorg Med Chem Lett, 20 (19): 5735-8. [PMID:20810280]