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YCT-529   Click here for help

GtoPdb Ligand ID: 11954

Synonyms: 
Compound class: Synthetic organic
Comment: YCT-529 is an oral retinoic acid receptor alpha (RAR-α; RARA) antagonist [4]. Its development and function were originally presented at the spring meeting of the American Chemical Society (ACS) in March 2022. YCT-529 has no detectable agonist activity, unlike a previously reported compound BMS-189453 which is an antagonist/partial agonist [3]. Antagonising RAR-α disrupts spermatogenesis.
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 4
Topological polar surface area 58.56
Molecular weight 435.51
XLogP 4.99
No. Lipinski's rules broken 0

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES CC1=CC=C(C=C1)C2=CC(C)(C)OC3=CC=C(C=C23)C4=CC=C(C5=CC=C(C=C5)C(=O)O)N4
Isomeric SMILES CC1=CC=C(C=C1)C2=CC(OC3=C2C=C(C=C3)C4=CC=C(N4)C5=CC=C(C=C5)C(=O)O)(C)C
InChI InChI=1S/C29H25NO3/c1-18-4-6-19(7-5-18)24-17-29(2,3)33-27-15-12-22(16-23(24)27)26-14-13-25(30-26)20-8-10-21(11-9-20)28(31)32/h4-17,30H,1-3H3,(H,31,32)
InChI Key QLXSCDXZOYRDAX-UHFFFAOYSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
References
1. Mannowetz N, Chung SSW, Maitra S, Noman MAA, Wong HL, Cheryala N, Bakshi A, Wolgemuth DJ, Georg GI. (2025)
Targeting the retinoid signaling pathway with YCT-529 for effective and reversible oral contraception in mice and primates.
Commun Med (Lond), 5 (1): 68. [PMID:40082579]
2. Mannowetz N, McCallum SW, Sidhu S, Mena KH, Ruby EP, Castro-Santamaria R, Dodds E, Henderson D, Whitaker G, Wright H et al.. (2025)
Safety and pharmacokinetics of the non-hormonal male contraceptive YCT-529.
Commun Med (Lond), 5 (1): 279. [PMID:40696162]
3. Shi R, Wolgemuth DJ, Georg GI. (2025)
Development of the retinoic acid receptor alpha-specific antagonist YCT-529 for male contraception: A brief review.
Contraception, 145: 110809. [PMID:39756562]
4. Taher N, Haque E, Georg GI. (2025)
From concept to the clinic: Retinoic acid receptor α antagonist YCT-529, an oral non-hormonal male contraceptive.
Andrology, [Epub ahead of print]. [PMID:40797283]