gremlin 1   Click here for help

GtoPdb Ligand ID: 11768

Compound class: Endogenous peptide in human, mouse or rat
Comment: Gremlin 1 is a member of a family of proteins (the DAN family) that are peptide antagonists of TGF-β family bone morphogenetic proteins (BMP) [4] including BMP2 and BMP4. DAN family members can also modulate Wnt and vascular endothelial growth factor (VEGF) signalling pathway activities. BMP/BMP antagonist interactions regulate developmental and normal cellular processes. In contrast, dysregulation of these interactions has been associated with pathological processes such as carcinogenesis and fibrosis. Gremlin 1 has emerged as a molecular target for the development of novel therapeutics for relevant conditions [1-3].
Species: Human
Classification Click here for help
Compound class Endogenous peptide in human, mouse or rat
Gene/Precursor Click here for help
Gene symbol Gene name Species Precursor protein name Synonyms
GREM1 gremlin 1, DAN family BMP antagonist Human gremlin-1 isoform 1 precursor -
Database Links Click here for help
Ensembl Gene ENSG00000166923 (Hs)
Entrez Gene 26585 (Hs)
GtoPdb PubChem SID 458923803
Human Protein Atlas ENSG00000166923 (Hs)
OMIM 603054 (Hs)
UniProtKB O60565 (Hs)