lacidipine   Click here for help

GtoPdb Ligand ID: 11740

Synonyms: GR-43659X | GR43659X | GX 1048 | GX-1048 | GX1048 | Lacipil® | Molap® | Motens®
Approved drug
lacidipine is an approved drug (UK (2013))
Compound class: Synthetic organic
Comment: Lacidipine (GR-43659X) is dihydropyridine calcium channel blocker. It has a slow onset of activity and a long duration of action.
2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 7
Hydrogen bond donors 1
Rotatable bonds 11
Topological polar surface area 90.93
Molecular weight 455.23
XLogP 5.77
No. Lipinski's rules broken 2
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Canonical SMILES CCOC(=O)C1=C(C)NC(=C(C1c1ccccc1/C=C/C(=O)OC(C)(C)C)C(=O)OCC)C
Isomeric SMILES CCOC(=O)C1=C(NC(=C(C1c1ccccc1/C=C/C(=O)OC(C)(C)C)C(=O)OCC)C)C
InChI InChI=1S/C26H33NO6/c1-8-31-24(29)21-16(3)27-17(4)22(25(30)32-9-2)23(21)19-13-11-10-12-18(19)14-15-20(28)33-26(5,6)7/h10-15,23,27H,8-9H2,1-7H3/b15-14+
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (UK (2013))
IUPAC Name Click here for help
diethyl 2,6-dimethyl-4-[2-[(E)-3-[(2-methylpropan-2-yl)oxy]-3-oxoprop-1-enyl]phenyl]-1,4-dihydropyridine-3,5-dicarboxylate
International Nonproprietary Names Click here for help
INN number INN
6093 lacidipine
Synonyms Click here for help
GR-43659X | GR43659X | GX 1048 | GX-1048 | GX1048 | Lacipil® | Molap® | Motens®
Database Links Click here for help
CAS Registry No. 103890-78-4 (source: WHO INN record)
DrugBank Ligand DB09236
GtoPdb PubChem SID 458923775
PubChem CID 5311217
Search Google for chemical match using the InChIKey GKQPCPXONLDCMU-CCEZHUSRSA-N
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UniChem Compound Search for chemical match using the InChIKey GKQPCPXONLDCMU-CCEZHUSRSA-N
UniChem Connectivity Search for chemical match using the InChIKey GKQPCPXONLDCMU-CCEZHUSRSA-N