Synonyms: ARV-110 | compound 406 [WO2018071606A1]
Compound class:
Synthetic organic
Comment: ARV110 is a bifunctional compound (PROTAC). One end of the molecule binds to the androgen receptor and the other binds to the cereblon E3 ligase and directs the AR for proteasome-mediated degradation [1]. It has clinical potential as an oral therapy for metastatic castration-resistant prostate cancer. PubChem CID 134414307 represents the molecule without specified stereo chemistry.
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Classification ![]() |
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Compound class | Synthetic organic |
Ligand families/groups | PROTACs, molecular glues and other degraders |
Synonyms ![]() |
ARV-110 | compound 406 [WO2018071606A1] |
Database Links ![]() |
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GtoPdb PubChem SID | 441604884 |
Search Google for chemical match using the InChIKey | CLCTZVRHDOAUGJ-SYVGMNBRSA-N |
Search Google for chemicals with the same backbone | CLCTZVRHDOAUGJ |
UniChem Compound Search for chemical match using the InChIKey | CLCTZVRHDOAUGJ-SYVGMNBRSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | CLCTZVRHDOAUGJ-SYVGMNBRSA-N |