serdexmethylphenidate   Click here for help

GtoPdb Ligand ID: 11450

Synonyms: Azstarys® (serdexmethylphenidate + dexmethylphenidate) | KP-484 | KP484
Approved drug
serdexmethylphenidate is an approved drug (FDA (2021))
Compound class: Synthetic organic
Comment: Serdexmethylphenidate (KP484) is a prodrug that is a slow-release derivative of dexmethylphenidate (d-MPH).
2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 10
Hydrogen bond donors 2
Rotatable bonds 13
Topological polar surface area 149.18
Molecular weight 499.2
XLogP 1.85
No. Lipinski's rules broken 1
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Canonical SMILES OC[C@@H](C(=O)[O-])NC(=O)c1ccc[n+](c1)COC(=O)N1CCCC[C@@H]1[C@@H](c1ccccc1)C(=O)OC
Isomeric SMILES OC[C@@H](C(=O)[O-])NC(=O)c1ccc[n+](c1)COC(=O)N1CCCC[C@@H]1[C@@H](c1ccccc1)C(=O)OC
InChI InChI=1S/C25H29N3O8/c1-35-24(33)21(17-8-3-2-4-9-17)20-11-5-6-13-28(20)25(34)36-16-27-12-7-10-18(14-27)22(30)26-19(15-29)23(31)32/h2-4,7-10,12,14,19-21,29H,5-6,11,13,15-16H2,1H3,(H-,26,30,31,32)/t19-,20+,21+/m0/s1
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (FDA (2021))
Is prodrug? Yes
Active form dexmethylphenidate
IUPAC Name Click here for help
International Nonproprietary Names Click here for help
INN number INN
10916 serdexmethylphenidate
Synonyms Click here for help
Azstarys® (serdexmethylphenidate + dexmethylphenidate) | KP-484 | KP484
Database Links Click here for help
CAS Registry No. 1996626-29-9 (source: WHO INN record)
GtoPdb PubChem SID 440816819
PubChem CID 134823895
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UniChem Compound Search for chemical match using the InChIKey UBZPNQRBUOBBLN-PWRODBHTSA-N
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