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oseltamivir   Click here for help

GtoPdb Ligand ID: 11427

Synonyms: GS-4104 | GS4104 | RO-640796 | RO640796 | Tamiflu® | Tamvir®
Approved drug
oseltamivir is an approved drug (FDA (1999), EMA (2002))
Compound class: Synthetic organic
Comment: Oseltamivir is an oral antiviral prodrug. Its active metabolite inhibits influenza neuraminidases and prevents new viral particles from being released from infected host cells.

oseltamivir is commercially available from our sponsors

2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Click here for structure editor
Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 9
Topological polar surface area 90.65
Molecular weight 312.2
XLogP 1.05
No. Lipinski's rules broken 0

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES CCOC(=O)C1=C[C@H]([C@@H]([C@H](C1)N)NC(=O)C)OC(CC)CC
Isomeric SMILES CCOC(=O)C1=C[C@H]([C@@H]([C@H](C1)N)NC(=O)C)OC(CC)CC
InChI InChI=1S/C16H28N2O4/c1-5-12(6-2)22-14-9-11(16(20)21-7-3)8-13(17)15(14)18-10(4)19/h9,12-15H,5-8,17H2,1-4H3,(H,18,19)/t13-,14+,15+/m0/s1
InChI Key VSZGPKBBMSAYNT-RRFJBIMHSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes. EU EMA (2002)  |  US FDA (1999)
WHO Essential Medicine WHO Essential Medicines List (EML) (23rd List, 2023). Access PDF version.
Click to view more information about the WHO Model Lists of Essential Medicines.
IUPAC Name Click here for help
ethyl (3R,4R,5S)-4-acetamido-5-amino-3-pentan-3-yloxycyclohexene-1-carboxylate
International Nonproprietary Names Click here for help
INN number INN
7793 oseltamivir
Synonyms Click here for help
GS-4104 | GS4104 | RO-640796 | RO640796 | Tamiflu® | Tamvir®
Database Links Click here for help
BindingDB Ligand 5025
CAS Registry No. 196618-13-0 (source: WHO INN record)
ChEMBL Ligand CHEMBL1229
DrugBank Ligand DB00198
GtoPdb PubChem SID 440816796
PubChem CID 65028
Search Google for chemical match using the InChIKey VSZGPKBBMSAYNT-RRFJBIMHSA-N
Search Google for chemicals with the same backbone VSZGPKBBMSAYNT
Search PubMed clinical trials oseltamivir
Search PubMed titles oseltamivir
Search PubMed titles/abstracts oseltamivir
UniChem Compound Search for chemical match using the InChIKey VSZGPKBBMSAYNT-RRFJBIMHSA-N
UniChem Connectivity Search for chemical match using the InChIKey VSZGPKBBMSAYNT-RRFJBIMHSA-N

Product suppliers

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Product supplier links are provided as a service to assist in identifying commercial suppliers of reagents that are mentioned on the IUPHAR/BPS Guide to PHARMACOLOGY database website, and do not imply their endorsement by NC-IUPHAR.

Links are provided in return for sponsorship, used to fund improvements to this database. The sponsorship account is managed and audited by the University of Edinburgh, a charitable body registered in Scotland, SC005336. If you are interested in sponsoring the database, please contact us.

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MedChemExpress
Oseltamivir (links to external site)
Cat. No. HY-13317