cefteram   Click here for help

GtoPdb Ligand ID: 11051

Synonyms: cefterame | ceftetrame | CFTM | Ro 19-5247 | T-2525
Approved drug
cefteram is an approved drug (Japan)
Compound class: Synthetic organic
Comment: Cefteram is a semisynthetic, third generation cephalosporin (β-lactam) compound with broad-spectrum antibacterial activity. To provide acceptable bioavailability for oral use it is formulated as a pivoxil ester prodrug (cefteram pivoxil, T-2588, PubChem CID 5362114).
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 11
Hydrogen bond donors 3
Rotatable bonds 8
Topological polar surface area 244.35
Molecular weight 479.08
XLogP -2.39
No. Lipinski's rules broken 1
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES CO/N=C(\C(=O)N[C@@H]1C(=O)N2[C@@H]1SCC(=C2C(=O)O)Cn1nnc(n1)C)/c1csc(n1)N
Isomeric SMILES CO/N=C(\C(=O)N[C@@H]1C(=O)N2[C@@H]1SCC(=C2C(=O)O)Cn1nnc(n1)C)/c1csc(n1)N
InChI InChI=1S/C16H17N9O5S2/c1-6-20-23-24(21-6)3-7-4-31-14-10(13(27)25(14)11(7)15(28)29)19-12(26)9(22-30-2)8-5-32-16(17)18-8/h5,10,14H,3-4H2,1-2H3,(H2,17,18)(H,19,26)(H,28,29)/b22-9-/t10-,14-/m1/s1
InChI Key XSPUSVIQHBDITA-RKYNPMAHSA-N
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (Japan)
IUPAC Name Click here for help
(6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-[(5-methyltetrazol-2-yl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
International Nonproprietary Names Click here for help
INN number INN
5947 cefteram
Synonyms Click here for help
cefterame | ceftetrame | CFTM | Ro 19-5247 | T-2525
Database Links Click here for help
Specialist databases
Antibiotic DB Antibiotic DB Database logo Ceftetrame (Ro15-8074), Ro 19-5247, T2525, tomiron, Cefteram, T-2588, cefteram pivoxil (prodrug)
Other databases
CAS Registry No. 82547-58-8 (source: Scifinder)
ChEMBL Ligand CHEMBL2105953
DrugCentral Ligand 3076
GtoPdb PubChem SID 405560492
PubChem CID 6537431
Search Google for chemical match using the InChIKey XSPUSVIQHBDITA-RKYNPMAHSA-N
Search Google for chemicals with the same backbone XSPUSVIQHBDITA
Search PubMed clinical trials cefteram
Search PubMed titles cefteram
Search PubMed titles/abstracts cefteram
UniChem Compound Search for chemical match using the InChIKey XSPUSVIQHBDITA-RKYNPMAHSA-N
UniChem Connectivity Search for chemical match using the InChIKey XSPUSVIQHBDITA-RKYNPMAHSA-N