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cefuroxime   Click here for help

GtoPdb Ligand ID: 10900

Synonyms: Ceftin® | CXM | Kefurox® | Zinacef®
Approved drug PDB Ligand
cefuroxime is an approved drug (FDA (1983))
Compound class: Synthetic organic
Comment: Cefuroxime is a semisynthetic, second-generation cephalosporin antibacterial. It has broad-spectrum activity and is β-lactamase-resistant. Oral formulations contain the prodrug cefuroxime axetil.

cefuroxime is commercially available from our sponsors

2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 9
Hydrogen bond donors 3
Rotatable bonds 9
Topological polar surface area 199.06
Molecular weight 424.07
XLogP -0.8
No. Lipinski's rules broken 0

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES CO/N=C(\C(=O)N[C@@H]1C(=O)N2[C@@H]1SCC(=C2C(=O)O)COC(=O)N)/c1ccco1
Isomeric SMILES CO/N=C(\C(=O)N[C@@H]1C(=O)N2[C@@H]1SCC(=C2C(=O)O)COC(=O)N)/c1ccco1
InChI InChI=1S/C16H16N4O8S/c1-26-19-9(8-3-2-4-27-8)12(21)18-10-13(22)20-11(15(23)24)7(5-28-16(17)25)6-29-14(10)20/h2-4,10,14H,5-6H2,1H3,(H2,17,25)(H,18,21)(H,23,24)/b19-9-/t10-,14-/m1/s1
InChI Key JFPVXVDWJQMJEE-IZRZKJBUSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes. US FDA (1983)
WHO Essential Medicine WHO Essential Medicines List (EML) (23rd List, 2023). Access PDF version.
Click to view more information about the WHO Model Lists of Essential Medicines.
IUPAC Name Click here for help
(6R,7R)-3-(carbamoyloxymethyl)-7-[[(2Z)-2-(furan-2-yl)-2-methoxyiminoacetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
International Nonproprietary Names Click here for help
INN number INN
3902 cefuroxime
Synonyms Click here for help
Ceftin® | CXM | Kefurox® | Zinacef®
Database Links Click here for help
Specialist databases
Antibiotic DB Antibiotic DB Database logo Cefuroxime
Reactome Drug Reactome logo R-ALL-9695388
Reactome Reaction Reactome logo R-HSA-9695415
Other databases
BindingDB Ligand 50422689
CAS Registry No. 55268-75-2 (source: WHO INN record)
ChEMBL Ligand CHEMBL1436
DrugBank Ligand DB01112
DrugCentral Ligand 565
GtoPdb PubChem SID 405560341
PubChem CID 5479529
RCSB PDB Ligand KOV
Search Google for chemical match using the InChIKey JFPVXVDWJQMJEE-IZRZKJBUSA-N
Search Google for chemicals with the same backbone JFPVXVDWJQMJEE
Search PubMed clinical trials cefuroxime
Search PubMed titles cefuroxime
Search PubMed titles/abstracts cefuroxime
UniChem Compound Search for chemical match using the InChIKey JFPVXVDWJQMJEE-IZRZKJBUSA-N
UniChem Connectivity Search for chemical match using the InChIKey JFPVXVDWJQMJEE-IZRZKJBUSA-N

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MedChemExpress
Cefuroxime (links to external site)
Cat. No. HY-B1256A