tomopenem   Click here for help

GtoPdb Ligand ID: 10869

Synonyms: CS-023 | CS023 | R-115685 | R115685 | RO-4908463
Compound class: Synthetic organic
Comment: Tomopenem is a carbapenem antibacterial [1-2,4]. It was reported to exhibit enhanced in vitro activity against oxacillin-resistant Staphylococci and Pseudomonas aeruginosa [5].
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 13
Hydrogen bond donors 5
Rotatable bonds 10
Topological polar surface area 220.19
Molecular weight 537.24
XLogP -4.75
No. Lipinski's rules broken 1

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES O=C(N[C@H]1CCN(C1)C(=O)[C@@H]1C[C@@H](CN1C)SC1=C(C(=O)O)N2[C@H]([C@H]1C)[C@H](C2=O)[C@H](O)C)CN=C(N)N
Isomeric SMILES O=C(N[C@H]1CCN(C1)C(=O)[C@@H]1C[C@@H](CN1C)SC1=C(C(=O)O)N2[C@H]([C@H]1C)[C@H](C2=O)[C@H](O)C)CN=C(N)N
InChI InChI=1S/C23H35N7O6S/c1-10-17-16(11(2)31)21(34)30(17)18(22(35)36)19(10)37-13-6-14(28(3)9-13)20(33)29-5-4-12(8-29)27-15(32)7-26-23(24)25/h10-14,16-17,31H,4-9H2,1-3H3,(H,27,32)(H,35,36)(H4,24,25,26)/t10-,11-,12+,13+,14+,16-,17-/m1/s1
InChI Key KEDAXBWZURNCHS-GPODMPQUSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
References
1. Koga T, Abe T, Inoue H, Takenouchi T, Kitayama A, Yoshida T, Masuda N, Sugihara C, Kakuta M, Nakagawa M et al.. (2005)
In vitro and in vivo antibacterial activities of CS-023 (RO4908463), a novel parenteral carbapenem.
Antimicrob Agents Chemother, 49 (8): 3239-50. [PMID:16048932]
2. Koga T, Sugihara C, Kakuta M, Masuda N, Namba E, Fukuoka T. (2009)
Affinity of Tomopenem (CS-023) for penicillin-binding proteins in Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa.
Antimicrob Agents Chemother, 53 (3): 1238-41. [PMID:19104025]
3. Shibayama T, Matsushita Y, Hirota T, Ikeda T, Kuwahara S. (2006)
Pharmacokinetics of CS-023 (RO4908463), a novel parenteral carbapenem, in healthy male Caucasian volunteers.
Antimicrob Agents Chemother, 50 (12): 4186-8. [PMID:17043123]
4. Tanaka K, Mikamo H, Nakao K, Ichiishi T, Goto T, Yamagishi Y, Watanabe K. (2009)
In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria.
Antimicrob Agents Chemother, 53 (1): 319-22. [PMID:18955522]
5. Thomson KS, Moland ES. (2004)
CS-023 (R-115685), a novel carbapenem with enhanced in vitro activity against oxacillin-resistant staphylococci and Pseudomonas aeruginosa.
J Antimicrob Chemother, 54 (2): 557-62. [PMID:15201229]