DASA-58   Click here for help

GtoPdb Ligand ID: 10556

Synonyms: compound 1 [PMID: 21958545] | DASA58 | ML-203 | ML203
PDB Ligand
Compound class: Synthetic organic
Comment: DASA-58 is an activator of tumour-associated pyruvate kinase M2 (PKM2) [2]. PKM2 activation has potential to interfere with the anabolic metabolic pathway that is utilised by cancer cells to maintain high levels of proliferation. Like TEPP-46, DASA-58 promotes formation of highly active PKM2 tetramers and suppresses tumour expansion in vivo [1].

DASA-58 is commercially available from our sponsors

2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 7
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 136
Molecular weight 453.1
XLogP 0.69
No. Lipinski's rules broken 0

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES Nc1cccc(c1)S(=O)(=O)N1CCCN(CC1)S(=O)(=O)c1ccc2c(c1)OCCO2
Isomeric SMILES Nc1cccc(c1)S(=O)(=O)N1CCCN(CC1)S(=O)(=O)c1ccc2c(c1)OCCO2
InChI InChI=1S/C19H23N3O6S2/c20-15-3-1-4-16(13-15)29(23,24)21-7-2-8-22(10-9-21)30(25,26)17-5-6-18-19(14-17)28-12-11-27-18/h1,3-6,13-14H,2,7-12,20H2
InChI Key GMHIOMMKSMSRLY-UHFFFAOYSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Classification Click here for help
Compound class Synthetic organic
IUPAC Name Click here for help
3-[[4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)-1,4-diazepan-1-yl]sulfonyl]aniline
Synonyms Click here for help
compound 1 [PMID: 21958545] | DASA58 | ML-203 | ML203
Database Links Click here for help
BindingDB Ligand 50361557
CAS Registry No. 1203494-49-8 (source: PubChem)
ChEMBL Ligand CHEMBL1089334
GtoPdb PubChem SID 404859004
PubChem CID 44543605
RCSB PDB Ligand 3SZ
Search Google for chemical match using the InChIKey GMHIOMMKSMSRLY-UHFFFAOYSA-N
Search Google for chemicals with the same backbone GMHIOMMKSMSRLY
UniChem Compound Search for chemical match using the InChIKey GMHIOMMKSMSRLY-UHFFFAOYSA-N
UniChem Connectivity Search for chemical match using the InChIKey GMHIOMMKSMSRLY-UHFFFAOYSA-N

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MedChemExpress
DASA-58 (links to external site)
Cat. No. HY-19330