- Guide to PHARMACOLOGY
Synonyms: example 129 [WO2011069063A2]  | SEP-363856 (parent molecule) | SEP-856 | SEP363856
Compound class: Synthetic organic
Comment: SEP-363856 is an orally active and brain-penetrant psychotropic agent with a novel mechanism of action. It acts as a trace amine-associated receptor 1 (TAAR1) agonist with additional 5-HT1A receptor agonist activity, and agonism at both of these receptors appears to be required for its clinical effects . SEP-363856 is being developed by Sunovion Pharmaceuticals and PsychoGenics, and was granted FDA Breakthrough Therapy Designation as an anti-schizophrenia therapeutic in May 2019. The lack of D2 receptor activity distinguishes SEP-363856 from current antipsychotic medications.
In the Dedic et al. article from 2019 SEP-363856 refers to the hydrochloride salt. We show the parent molecule here. This S enantiomer is more active at TAAR1 compared to the R stereoenantiomer .
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
|Compound class||Synthetic organic|
|example 129 [WO2011069063A2]  | SEP-363856 (parent molecule) | SEP-856 | SEP363856|
|GtoPdb PubChem SID||385612214|
|Search Google for chemical match using the InChIKey||ABDDQTDRAHXHOC-QMMMGPOBSA-N|
|Search Google for chemicals with the same backbone||ABDDQTDRAHXHOC|
|Search UniChem for chemical match using the InChIKey||ABDDQTDRAHXHOC-QMMMGPOBSA-N|
|Search UniChem for chemicals with the same backbone||ABDDQTDRAHXHOC|