ulinastatin   Click here for help

GtoPdb Ligand ID: 10359

Synonyms: Miraclid® | Ulinase® | Urinastatin®
Approved drug Immunopharmacology Ligand
ulinastatin is an approved drug (Japan, China)
Compound class: Endogenous peptide in human, mouse or rat
Comment: Ulinastatin is considered to be a metabolite of inter-α-trypsin inhibitor (ITI) that is one of the cleavage products from the AMBP precursor protein [3]. Compared to full length ITI, ulinastatin lacks the carboxyterminal RFSN amino acids. Functionally ulinastatin is a protease inhibitor, that plays an important role in physiological and pathological processes, and has notable anti-inflammatory activity [1-2,6]. It can be purified from healthy human urine or produced using recombinant technology.
Species: Human
Classification Click here for help
Compound class Endogenous peptide in human, mouse or rat
Approved drug? Yes. Japan (0)  |  China (0)
International Nonproprietary Names Click here for help
INN number INN
5938 ulinastatin
Synonyms Click here for help
Miraclid® | Ulinase® | Urinastatin®
Gene/Precursor Click here for help
Gene symbol Gene name Species Precursor protein name Synonyms
AMBP alpha-1-microglobulin/bikunin precursor Human -
Database Links Click here for help
Ensembl Gene ENSG00000106927 (Hs)
GtoPdb PubChem SID 387271625
Human Protein Atlas ENSG00000106927 (Hs)
OMIM 176870 (Hs)
Search PubMed clinical trials ulinastatin
Search PubMed titles ulinastatin
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UniProtKB P02760 (Hs)