Synonyms: compound 3 [PMID: 30272974]
Compound class:
Synthetic organic
Comment: Diprovocim-1 is a highly potent, synthetic TLR1/TLR2 agonist [1]. It is structurally disctinct from other known natural or synthetic lipoprotein TLR agonists. Mechanistically it promotes the formation of TLR2 dimers and TLR2/TLR1 heterodimers in vitro [2]. The structure shown here was drawn from Morin et al. (2018) [1]. PubChem hold a record for Diprovocim that shows alternative stereochemistry (CID 134817267).
![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Classification ![]() |
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Compound class | Synthetic organic |
IUPAC Name ![]() |
(3S,4S)-1-{4-[(3S,4S)-3,4-bis({[(1S,2R)-2-phenylcyclopropyl]carbamoyl})pyrrolidine-1-carbonyl]benzoyl}-N3,N4-bis[(1S,2R)-2-phenylcyclopropyl]pyrrolidine-3,4-dicarboxamide |
Synonyms ![]() |
compound 3 [PMID: 30272974] |
Database Links ![]() |
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GtoPdb PubChem SID | 381745022 |
PubChem CID | 137553173 |
RCSB PDB Ligand | KQD |
Search Google for chemical match using the InChIKey | ABZBNXFGYUSVCJ-UYMKNZQYSA-N |
Search Google for chemicals with the same backbone | ABZBNXFGYUSVCJ |
UniChem Compound Search for chemical match using the InChIKey | ABZBNXFGYUSVCJ-UYMKNZQYSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | ABZBNXFGYUSVCJ-UYMKNZQYSA-N |