- Guide to PHARMACOLOGY
Synonyms: ICI-46474 | Nolvadex® | Soltamox®
tamoxifen is an approved drug (FDA (1977))
Compound class: Synthetic organic
Comment: Tamoxifen can be classed as a mixed agonist/antagonist of the estrogen -α and -β receptors, as its activity depends on the tissue in which the receptor is expressed. ChEMBL classify this compound as an ERα modulator, while it is described as a selective estrogen receptor modulator by Burris et al. in their 2013 review . Tamoxifen can be considered as a prodrug as its three main metabolites exhibit higher affinity and specificity than tamoxifen at the ERα and ERβ receptors.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
|Compound class||Synthetic organic|
|Approved drug?||Yes (FDA (1977))|
|WHO Essential Medicine||WHO Essential Medicines List (EML) (22nd List, 2021). Access PDF version.
Click to view more information about the WHO Model Lists of Essential Medicines.
|Active form||4-hydroxytamoxifen, norendoxifen, endoxifen|
|International Nonproprietary Names|
|ICI-46474 | Nolvadex® | Soltamox®|
|CAS Registry No.||10540-29-1 (source: Scifinder)|
|GtoPdb PubChem SID||135651233|
|RCSB PDB Ligand||CTX|
|Search Google for chemical match using the InChIKey||NKANXQFJJICGDU-QPLCGJKRSA-N|
|Search Google for chemicals with the same backbone||NKANXQFJJICGDU|
|Search PubMed clinical trials||tamoxifen|
|Search PubMed titles||tamoxifen|
|Search PubMed titles/abstracts||tamoxifen|
|UniChem Compound Search for chemical match using the InChIKey||NKANXQFJJICGDU-QPLCGJKRSA-N|
|UniChem Connectivity Search for chemical match using the InChIKey||NKANXQFJJICGDU-QPLCGJKRSA-N|
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Cat. No. 6342