Synonyms: ICZ | ICZ-carbazole
Compound class:
Synthetic organic
Comment: Indolo(3,2-b)carbazole is a potent agonist of the aryl hydrocarbon receptor (AhR) [1]. It is a metabolite of indole-3-carbinol (I3C) whihc is found in Brassica family vegetables, and which is formed in the acid pH of the stomach.
![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
|
Bioactivity Comments |
In vivo, indolo(3,2-b)carbazole induces cytochrome P4501A1 activity with an EC50 of 269 nM (in murine hepatoma Hepa 1c1c7 cells using an assay that measures ethoxyresorufin O-deethylase activity) [1]. |
Selectivity at other protein targets | ||||||||||||||||||||||||||||||||||
Key to terms and symbols | Click column headers to sort | |||||||||||||||||||||||||||||||||
|