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Stephen P.H. Alexander Associate Professor in Molecular Pharmacology Life Sciences E Floor University of Nottingham Medical School Nottingham NG7 2UH UK Patrick Doherty Wolfson Centre for Age-Related Diseases Kings College London Wolfson Wing, Hodgkin Building Guys Campus London SE1 1UL UK Christopher J. Fowler Building 6B, 2nd floor, University Hospital of Umeå SE-90187 Umeå Sweden Jürg Gertsch Institute of Biochemistry and Molecular Medicine University of Bern Bühlstrasse 28, CH-3012 Bern Switzerland Mario van der Stelt Department of Molecular Physiology Leiden Institute of Chemistry Leiden University 2333 CC Leiden The Netherlands