2.3.1.48 Histone acetyltransferases (HATs)

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Chromatin modifying enzymes
2.3.1.48 Histone acetyltransferases (HATs)

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Enzymes

clock circadian regulator Show summary »« Hide summary

elongator acetyltransferase complex subunit 3 Show summary »« Hide summary

general transcription factor IIIC subunit 4 Show summary »« Hide summary

Target Id

2656

Nomenclature

general transcription factor IIIC subunit 4

Previous and unofficial names

KAT12 | TFIIIC90 | general transcription factor IIIC, polypeptide 4, 90kDa | general transcription factor IIIC, polypeptide 4 | general transcription factor IIIC

Genes

GTF3C4 (Hs), Gtf3c4 (Mm), Gtf3c4 (Rn)

Ensembl ID

ENSG00000125484 (Hs), ENSMUSG00000035666 (Mm), ENSRNOG00000054725 (Rn)

UniProtKB AC

Q9UKN8 (Hs), Q8BMQ2 (Mm)

EC number

2.3.1.48

histone acetyltransferase 1 Show summary »« Hide summary

jumonji domain containing 1C Show summary »« Hide summary

lysine acetyltransferase 5 Show summary »« Hide summary

lysine acetyltransferase 2A Show summary »« Hide summary More detailed page go icon to follow link

lysine acetyltransferase 6A Show summary »« Hide summary

lysine acetyltransferase 6B Show summary »« Hide summary

Target Id

2666

Nomenclature

lysine acetyltransferase 6B

Previous and unofficial names

MORF | MYST4 | K(lysine) acetyltransferase 6B

Genes

KAT6B (Hs), Kat6b (Mm)

Ensembl ID

ENSG00000156650 (Hs), ENSMUSG00000021767 (Mm)

UniProtKB AC

Q8WYB5 (Hs), Q8BRB7 (Mm)

EC number

2.3.1.48

Selective inhibitors

prifetrastat pK_i 8.4 [1]

PF-9363 pIC₅₀ 8.6 [7]

lysine acetyltransferase 2B Show summary »« Hide summary More detailed page go icon to follow link

Target Id	2737
Nomenclature	lysine acetyltransferase 2B
Previous and unofficial names	GCN5 \| GCN5L \| PCAF \| Pcaf \| p300/CBP-associated factor \| K(lysine) acetyltransferase 2B
Genes	KAT2B (Hs), Kat2b (Mm), Kat2b (Rn)
Ensembl ID	ENSG00000114166 (Hs), ENSMUSG00000000708 (Mm), ENSRNOG00000011871 (Rn)
UniProtKB AC	Q92831 (Hs), Q9JHD1 (Mm)

lysine acetyltransferase 7 Show summary »« Hide summary

lysine acetyltransferase 8 Show summary »« Hide summary

Target Id

2668

Nomenclature

lysine acetyltransferase 8

Previous and unofficial names

HMOF | MYST1 | K(lysine) acetyltransferase 8 | K (lysine) acetyltransferase 8

Genes

KAT8 (Hs), Kat8 (Mm), Kat8 (Rn)

Ensembl ID

ENSG00000103510 (Hs), ENSMUSG00000030801 (Mm), ENSRNOG00000019485 (Rn)

UniProtKB AC

Q9H7Z6 (Hs), Q5XI06 (Rn)

EC number

2.3.1.48

Selective inhibitors

MG149 pIC₅₀ 4.3 [3]

nuclear receptor coactivator 1 Show summary »« Hide summary More detailed page go icon to follow link

nuclear receptor coactivator 2 Show summary »« Hide summary

nuclear receptor coactivator 3 Show summary »« Hide summary

References

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1. Bozikis YEB, Brodsky O, Camerino MA, Greasley SE, Hoffman RL, Kumpf RA, Kung PP, Richardson PF, Stupple PA, Sutton SC. (2020) Benzisoxazole sulfonamide derivatives. Patent number: WO2020254946A1. Assignee: Pfizer Inc., Ctxt Pty Ltd. Priority date: 16/06/2020. Publication date: 24/12/2020.

2. Cheng X, Qin L, ren F. (2024) Lysine acetyltransferase 6A (KAT6A) inhibitors and uses thereof. Patent number: US12091406B2. Assignee: InSilico Medicine IP Ltd. Priority date: 13/11/2023. Publication date: 17/09/2024.

3. Ghizzoni M, Wu J, Gao T, Haisma HJ, Dekker FJ, George Zheng Y. (2012) 6-alkylsalicylates are selective Tip60 inhibitors and target the acetyl-CoA binding site. Eur J Med Chem, 47 (1): 337-44. [PMID:22100137]

4. Liang J, Wang D, Wu Y, Shi J, Xie B, Xiao R, Ni J, Wang C, Dong C, Shu HB et al.. (2025) Intercepting the Downstream of the Estrogen Receptor Signaling Pathway: Discovery of a Potent and Efficient SRC-3 PROTAC Degrader for Overcoming Endocrine Resistance Breast Cancer. J Med Chem, 68 (11): 11516-11542. [PMID:40434408]

5. Lu D, Chen J, Qin L, Bijou I, Yi P, Li F, Song X, MacKenzie KR, Yu X, Yang B et al.. (2024) Lead Compound Development of SRC-3 Inhibitors with Improved Pharmacokinetic Properties and Anticancer Efficacy. J Med Chem, 67 (7): 5333-5350. [PMID:38551814]

6. Pawley S, Buesking AW, Combs AP. (2023) Kat6 targeting compounds with ubiquitin ligase binding moiety. Patent number: WO2023245150A1. Assignee: Prelude Therapeutics Incorporated. Priority date: 16/06/2023. Publication date: 21/12/2023.

7. Sharma S, Chung CY, Uryu S, Petrovic J, Cao J, Rickard A, Nady N, Greasley S, Johnson E, Brodsky O et al.. (2023) Discovery of a highly potent, selective, orally bioavailable inhibitor of KAT6A/B histone acetyltransferases with efficacy against KAT6A-high ER+ breast cancer. Cell Chem Biol, 30 (10): 1191-1210.e20. [PMID:37557181]

8. Stellwagen JC, Adjabeng GM, Arnone MR, Dickerson SH, Han C, Hornberger KR, King AJ, Mook Jr RA, Petrov KG, Rheault TR et al.. (2011) Development of potent B-RafV600E inhibitors containing an arylsulfonamide headgroup. Bioorg Med Chem Lett, 21 (15): 4436-40. [PMID:21733693]

How to cite this family page

Database page citation:

2.3.1.48 Histone acetyltransferases (HATs). Accessed on 15/09/2025. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=872.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.