programmed cell death 1 ligand 1 
GtoPdb Ligand ID: 9606
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Abbreviated name: PD-L1
Synonyms: B7 homolog 1 | B7-H1 | PDL1 | programmed death ligand 1
Compound class:
Endogenous peptide in human, mouse or rat
Comment: This is one of the ligands for the PD-1 receptor. It is a single-pass type I membrane protein. The PD-L1/PD-1 interaction is an established immune checkpoint. Both the ligand and receptor are targets for novel immuno-oncology therapeutics, as over-expression of either of these proteins is a mechanism used by tumour cells to evade immune detection and destruction. Already the target of approved immunotherapeutics in the form of monoclonal antibodies, small molecules targeting the PD-1/PD-L1 checkpoint are now in development to address the shortcomings associated with the current antibody therapies (including, poor susceptibility rate to single immune checkpoint pathway inhibitors, long half-life of antibodies and association with the development of adverse events, problems connected to the requirement for intravenous infusions) [7,16].
Species: Human
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Classification  |
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| Compound class | Endogenous peptide in human, mouse or rat |
| Ligand families/groups | Immune checkpoint modulators |
| Synonyms |
| B7 homolog 1 | B7-H1 | PDL1 | programmed death ligand 1 |
| Gene/Precursor |
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| Database Links |
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| CATH/Gene3D | 2.60.40.10 |
| Ensembl Gene | ENSG00000120217 (Hs) |
| Entrez Gene | 29126 (Hs) |
| GtoPdb PubChem SID | 340590236 |
| Human Protein Atlas | ENSG00000120217 (Hs) |
| OMIM | 605402 (Hs) |
| RefSeq Nucleotide | NM_014143 (Hs) |
| RefSeq Protein | NP_054862 (Hs) |
| UniProtKB | Q9NZQ7 (Hs) |
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