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Type III RTKs: PDGFR, CSFR, Kit, FLT3 receptor family C

Formerly known as: PDGF (platelet-derived growth factor) receptor family

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Type III RTKs include PDGFR, CSF-1R (Ems), Kit and FLT3, which function as homo- or heterodimers. Endogenous ligands of PDGF receptors are homo- or heterodimeric: PDGFA, PDGFB, VEGFE and PDGFD (PDGFD, Q9GZP0) combine as homo- or heterodimers to activate homo- or heterodimeric PDGF receptors. SCF is a dimeric ligand for KIT. Ligands for CSF1R are either monomeric or dimeric glycoproteins, while the endogenous agonist for FLT3 is a homodimer.

Receptors

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PDGFRα (platelet derived growth factor receptor alpha) C Show summary » More detailed page go icon to follow link

PDGFRβ (platelet derived growth factor receptor beta) C Show summary » More detailed page go icon to follow link

Kit (KIT proto-oncogene, receptor tyrosine kinase) C Show summary » More detailed page go icon to follow link

CSFR (colony stimulating factor 1 receptor) C Show summary » More detailed page go icon to follow link

FLT3 (fms related receptor tyrosine kinase 3) C Show summary » More detailed page go icon to follow link

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References

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How to cite this family page

Database page citation:

Type III RTKs: PDGFR, CSFR, Kit, FLT3 receptor family. Accessed on 11/12/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=322.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Catalytic receptors. Br J Pharmacol. 180 Suppl 2:S241-288.