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Decarboxylases C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The decarboxylases generate CO2 and the indicated products from acidic substrates, requiring pyridoxal 5-phosphate or pyruvic acid as a co-factor.

Enzymes

1270
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GAD1 (Glutamic acid decarboxylase 1) C Show summary »

GAD2 (Glutamic acid decarboxylase 2) C Show summary »

HDC (Histidine decarboxylase) C Show summary »

ADC (L-Arginine decarboxylase ) C Show summary »


Target Id 1270
Nomenclature L-Arginine decarboxylase
Common abbreviation ADC
Previous and unofficial names ODC1L | ODC-p | ADC | AZIN2 | Odcp | arginine decarboxylase | Adc
Genes AZIN2 (Hs), Azin2 (Mm), Azin2 (Rn)
Ensembl ID ENSG00000142920 (Hs), ENSMUSG00000028789 (Mm), ENSRNOG00000051507 (Rn)
UniProtKB AC Q96A70 (Hs), Q8BVM4 (Mm)
EC number
4.1.1.19
Endogenous substrates
L-arginine
Products
agmatine [10]
Cofactors
pyridoxal 5-phosphate
Comment The presence of a functional ADC activity in human tissues has been questioned [1].

AADC (L-Aromatic amino-acid decarboxylase ) C Show summary » More detailed page go icon to follow link

MLYCD (Malonyl-CoA decarboxylase) C Show summary » More detailed page go icon to follow link

ODC (Ornithine decarboxylase) C Show summary » More detailed page go icon to follow link

PSDC (Phosphatidylserine decarboxylase ) C Show summary »

SAMDC (S-Adenosylmethionine decarboxylase ) C Show summary »

References

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How to cite this family page

Database page citation:

Decarboxylases. Accessed on 14/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=256.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.