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Decarboxylases C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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The decarboxylases generate CO2 and the indicated products from acidic substrates, requiring pyridoxal 5-phosphate or pyruvic acid as a co-factor.


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GAD1 (Glutamic acid decarboxylase 1) C Show summary »

GAD2 (Glutamic acid decarboxylase 2) C Show summary »

HDC (Histidine decarboxylase) C Show summary »

ADC (L-Arginine decarboxylase ) C Show summary »

AADC (L-Aromatic amino-acid decarboxylase ) C Show summary » More detailed page go icon to follow link

MLYCD (Malonyl-CoA decarboxylase) C Show summary » More detailed page go icon to follow link

ODC (Ornithine decarboxylase) C Show summary » More detailed page go icon to follow link

PSDC (Phosphatidylserine decarboxylase ) C Show summary »

SAMDC (S-Adenosylmethionine decarboxylase ) C Show summary »

Target Id 1269
Nomenclature S-Adenosylmethionine decarboxylase
Common abbreviation SAMDC
Previous and unofficial names S-adenosylmethionine decarboxylase 1 | Amd1a | Amd1b | S-Adenosylmethionine decarboxylase 1A | S-Adenosylmethionine decarboxylase 1B | SAMDC
Genes AMD1 (Hs), Amd1 (Mm), Amd1 (Rn)
Ensembl ID ENSG00000123505 (Hs), ENSMUSG00000075232 (Mm), ENSRNOG00000000585 (Rn)
UniProtKB AC P17707 (Hs), P31154 (Mm), P17708 (Rn)
EC number
Endogenous substrates
S-adenosyl methionine
pyruvic acid
Selective inhibitors
sardomozide pIC50 8.0 [7]
Comment S-allylglycine is also an inhibitor of SAMDC [4].


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How to cite this family page

Database page citation:

Decarboxylases. Accessed on 30/05/2024. IUPHAR/BPS Guide to PHARMACOLOGY,

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.