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Peptide transporter 3

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Target id: 986

Nomenclature: Peptide transporter 3

Abbreviated Name: PHT2

Systematic Nomenclature: SLC15A3

Family: SLC15 family of peptide transporters

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 12 581 11q12.2 SLC15A3 solute carrier family 15 member 3
Mouse 12 578 19 A Slc15a3 solute carrier family 15, member 3
Rat 12 582 1q43 Slc15a3 solute carrier family 15 member 3
Previous and Unofficial Names Click here for help
solute carrier family 15 | peptide/histidine transporter PHT2 | PTR3 | solute carrier family 15 member 3 | solute carrier family 15 (oligopeptide transporter), member 3
Database Links Click here for help
Specialist databases
Bioparadigms SLC Tables SLC15A3 (Hs)
Other databases
Ensembl Gene
Entrez Gene
Human Protein Atlas
Substrates and Reaction Kinetics Click here for help
Substrate Sp. Property Value Units Standard property Standard value Assay description Assay conditions Comments Reference
valacyclovir Hs - - 5
cefadroxil Hs - - 5
muramyl dipeptide Hs - - 1,4
histidyl-leucine Substrate is endogenous in the given species Hs - - 2
glycyl-sarcosine Hs - - 5
MDP-rhodamine Hs - - 1
Tri-DAP Hs - - 4
Stoichiometry Click here for help
PHT2 has not been analyzed systematically with respect to driving force, mode of transport, and substrate specificity. The pH dependence observed for transport of histidine [2] and the model peptides used, i.e., carnosine [2] and histidyl-leucine [2], suggest a similar mode of operation as PEPT1 and PEPT2 proteins.
Other Binding Ligands
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Value Parameter Reference
[14C]histidine Small molecule or natural product Click here for species-specific activity table Ligand is labelled Ligand is radioactive Hs - - - 2
[3H]histidine Small molecule or natural product Click here for species-specific activity table Ligand is labelled Ligand is radioactive Hs - - - 2
Immunopharmacology Comments
SLC15A3 and SLC15A4 are preferentially expressed by cells within the lymphatic system, including dendritic cells. Expression of these two genes is upregulated in response to TLR stimulation [1,3]. There is some experimental evidence which suggests that SLC15A3 plays an important role in regulating TLR4-mediated inflammatory responses [3].
Cell Type Associations
Immuno Cell Type:  Dendritic cells
Cell Ontology Term:   dendritic cell (CL:0000451)
References:  1


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1. Nakamura N, Lill JR, Phung Q, Jiang Z, Bakalarski C, de Mazière A, Klumperman J, Schlatter M, Delamarre L, Mellman I. (2014) Endosomes are specialized platforms for bacterial sensing and NOD2 signalling. Nature, 509 (7499): 240-4. [PMID:24695226]

2. Sakata K, Yamashita T, Maeda M, Moriyama Y, Shimada S, Tohyama M. (2001) Cloning of a lymphatic peptide/histidine transporter. Biochem J, 356 (Pt 1): 53-60. [PMID:11336635]

3. Song F, Yi Y, Li C, Hu Y, Wang J, Smith DE, Jiang H. (2018) Regulation and biological role of the peptide/histidine transporter SLC15A3 in Toll-like receptor-mediated inflammatory responses in macrophage. Cell Death Dis, 9 (7): 770. [PMID:29991810]

4. Wang Y, Hu Y, Li P, Weng Y, Kamada N, Jiang H, Smith DE. (2018) Expression and regulation of proton-coupled oligopeptide transporters in colonic tissue and immune cells of mice. Biochem Pharmacol, 148: 163-173. [PMID:29305856]

5. Wang Y, Li P, Song F, Yang X, Weng Y, Ma Z, Wang L, Jiang H. (2019) Substrate Transport Properties of the Human Peptide/Histidine Transporter PHT2 in Transfected MDCK Cells. J Pharm Sci, 108 (10): 3416-3424. [PMID:31254495]


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