Contents:
- Gene and Protein Information
- Previous and Unofficial Names
- Database Links
- Natural/Endogenous Ligands
- Agonists
- Immunopharmacology Comments
- Immuno Process Associations
- Transduction Mechanisms
- Tissue Distribution
- Expression Datasets
- Functional Assays
- Physiological Functions
- Phenotypes, Alleles and Disease Models
- Biologically Significant Variants
- References
- Contributors
- How to cite this page
Gene and Protein Information  |
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| class A G protein-coupled receptor | ||||||
| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | 7 | 342 | 3p21.31 | CXCR6 | C-X-C motif chemokine receptor 6 | 3,7-8 |
| Mouse | 7 | 351 | 9 74.57 cM | Cxcr6 | chemokine (C-X-C motif) receptor 6 | 9 |
| Rat | 7 | 351 | 8 | Cxcr6 | C-X-C motif chemokine receptor 6 | |
| Previous and Unofficial Names |
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| BONZO [9] | TYMSTR [8] | CD186 | STRL33 [7] | chemokine (C-X-C motif) receptor 6 | |
| Database Links |
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| Specialist databases | |
| GPCRdb | cxcr6_human (Hs), cxcr6_mouse (Mm) |
| Other databases | |
| Alphafold | O00574 (Hs), Q9EQ16 (Mm) |
| ChEMBL Target | CHEMBL5994 (Hs), CHEMBL4630853 (Mm) |
| Ensembl Gene | ENSG00000172215 (Hs), ENSMUSG00000048521 (Mm), ENSRNOG00000006319 (Rn) |
| Entrez Gene | 10663 (Hs), 80901 (Mm), 100124593 (Rn) |
| Human Protein Atlas | ENSG00000172215 (Hs) |
| KEGG Gene | hsa:10663 (Hs), mmu:80901 (Mm), rno:100124593 (Rn) |
| OMIM | 605163 (Hs) |
| Pharos | O00574 (Hs) |
| RefSeq Nucleotide | NM_006564 (Hs), NM_030712 (Mm), NM_001102587 (Rn) |
| RefSeq Protein | NP_006555 (Hs), NP_109637 (Mm), NP_001096057 (Rn) |
| UniProtKB | O00574 (Hs), Q9EQ16 (Mm) |
| Wikipedia | CXCR6 (Hs) |
| Natural/Endogenous Ligands |
| CXCL16 {Sp: Human} , CXCL16 {Sp: Mouse} , CXCL16 {Sp: Rat} |
Download all structure-activity data for this target as a CSV file 
| Agonists | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Key to terms and symbols | Click column headers to sort | ||||||||||||||||||||||||||||||||||||||||||||||||||
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| Agonist Comments | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Mouse CXCL16 has also been cloned [11]. CXCL16 is identical to SR-PSOX, an acronym for its ability to function as a scavenger receptor that binds phosphatidylserine and oxidized lipoprotein [2]. | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Immunopharmacology Comments |
| CXCR6 is one of more than 20 distinct chemokine receptors expressed in human leukocytes. Chemokines primarily act to promote leukocyte chemotaxis to sites of inflammation. CXCR6 is upregulated by IL-2 and IL-15 [14]. |
| Immuno Process Associations | |||||||||||||||
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| Primary Transduction Mechanisms
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| Transducer | Effector/Response |
| Gi/Go family | |
| Comments: CXCR6 functional assays also include Gi independent adhesion to CXCL16 expressing surfaces [12] and HIV-1 and SIV envelope glycoprotein-mediated cell-cell fusion or HIV-1 and SIV infectivity [3,7] | |
| References: 1,9 | |
| Tissue Distribution
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| Expression Datasets |
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| Functional Assays
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| Physiological Functions
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| Phenotypes, Alleles and Disease Models
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Mouse data from MGI | ||||||||||||||||||||||||
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| Biologically Significant Variants
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References
1. Chandrasekar B, Bysani S, Mummidi S. (2004) CXCL16 signals via Gi, phosphatidylinositol 3-kinase, Akt, I kappa B kinase, and nuclear factor-kappa B and induces cell-cell adhesion and aortic smooth muscle cell proliferation. J Biol Chem, 279 (5): 3188-96. [PMID:14625285]
2. Cyster JG. (1999) Chemokines and cell migration in secondary lymphoid organs. Science, 286 (5447): 2098-102. [PMID:10617422]
3. Deng HK, Unutmaz D, KewalRamani VN, Littman DR. (1997) Expression cloning of new receptors used by simian and human immunodeficiency viruses. Nature, 388 (6639): 296-300. [PMID:9230441]
4. Duggal P, An P, Beaty TH, Strathdee SA, Farzadegan H, Markham RB, Johnson L, O'Brien SJ, Vlahov D, Winkler CA. (2003) Genetic influence of CXCR6 chemokine receptor alleles on PCP-mediated AIDS progression among African Americans. Genes Immun, 4 (4): 245-50. [PMID:12761559]
5. Honczarenko M, Le Y, Swierkowski M, Ghiran I, Glodek AM, Silberstein LE. (2006) Human bone marrow stromal cells express a distinct set of biologically functional chemokine receptors. Stem Cells, 24 (4): 1030-41. [PMID:16253981]
6. Kim CH, Kunkel EJ, Boisvert J, Johnston B, Campbell JJ, Genovese MC, Greenberg HB, Butcher EC. (2001) Bonzo/CXCR6 expression defines type 1-polarized T-cell subsets with extralymphoid tissue homing potential. J Clin Invest, 107 (5): 595-601. [PMID:11238560]
7. Liao F, Alkhatib G, Peden KW, Sharma G, Berger EA, Farber JM. (1997) STRL33, A novel chemokine receptor-like protein, functions as a fusion cofactor for both macrophage-tropic and T cell line-tropic HIV-1. J Exp Med, 185 (11): 2015-23. [PMID:9166430]
8. Loetscher M, Amara A, Oberlin E, Brass N, Legler D, Loetscher P, D'Apuzzo M, Meese E, Rousset D, Virelizier JL et al.. (1997) TYMSTR, a putative chemokine receptor selectively expressed in activated T cells, exhibits HIV-1 coreceptor function. Curr Biol, 7 (9): 652-60. [PMID:9285716]
9. Matloubian M, David A, Engel S, Ryan JE, Cyster JG. (2000) A transmembrane CXC chemokine is a ligand for HIV-coreceptor Bonzo. Nat Immunol, 1 (4): 298-304. [PMID:11017100]
10. Nakayama T, Hieshima K, Izawa D, Tatsumi Y, Kanamaru A, Yoshie O. (2003) Cutting edge: profile of chemokine receptor expression on human plasma cells accounts for their efficient recruitment to target tissues. J Immunol, 170 (3): 1136-40. [PMID:12538668]
11. Schweickart VL, Epp A, Raport CJ, Gray PW. (2000) CCR11 is a functional receptor for the monocyte chemoattractant protein family of chemokines. J Biol Chem, 75: 9550-9556. [PMID:10734104]
12. Shimaoka T, Nakayama T, Fukumoto N, Kume N, Takahashi S, Yamaguchi J, Minami M, Hayashida K, Kita T, Ohsumi J et al.. (2004) Cell surface-anchored SR-PSOX/CXC chemokine ligand 16 mediates firm adhesion of CXC chemokine receptor 6-expressing cells. J Leukoc Biol, 75 (2): 267-74. [PMID:14634054]
13. Thomas SY, Hou R, Boyson JE, Means TK, Hess C, Olson DP, Strominger JL, Brenner MB, Gumperz JE, Wilson SB et al.. (2003) CD1d-restricted NKT cells express a chemokine receptor profile indicative of Th1-type inflammatory homing cells. J Immunol, 171 (5): 2571-80. [PMID:12928408]
14. Unutmaz D, Xiang W, Sunshine MJ, Campbell J, Butcher E, Littman DR. (2000) The primate lentiviral receptor Bonzo/STRL33 is coordinately regulated with CCR5 and its expression pattern is conserved between human and mouse. J Immunol, 165 (6): 3284-92. [PMID:10975845]
15. Wilbanks A, Zondlo SC, Murphy K, Mak S, Soler D, Langdon P, Andrew DP, Wu L, Briskin M. (2001) Expression cloning of the STRL33/BONZO/TYMSTRligand reveals elements of CC, CXC, and CX3C chemokines. J Immunol, 166 (8): 5145-54. [PMID:11290797]
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