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Contents:
- Gene and Protein Information
- Previous and Unofficial Names
- Database Links
- Natural/Endogenous Ligands
- Agonists
- Antagonists
- Immunopharmacology Comments
- Immuno Process Associations
- Transduction Mechanisms
- Tissue Distribution
- Expression Datasets
- Functional Assays
- Physiological Functions
- Phenotypes, Alleles and Disease Models
- References
- Contributors
- How to cite this page
Gene and Protein Information  |
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| class A G protein-coupled receptor | ||||||
| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | 7 | 362 | 17q21.2 | CCR10 | C-C motif chemokine receptor 10 | 2-3,7,9,13 |
| Mouse | 7 | 362 | 11 64.34 cM | Ccr10 | C-C motif chemokine receptor 10 | 7,12-13 |
| Rat | 7 | - | 10q32.1 | Ccr10 | C-C motif chemokine receptor 10 | |
| Previous and Unofficial Names |
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| GPR-2 [4,13] | |
| Database Links |
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| Specialist databases | |
| GPCRdb | ccr10_human (Hs), ccr10_mouse (Mm) |
| Other databases | |
| Alphafold | P46092 (Hs), Q9JL21 (Mm) |
| ChEMBL Target | CHEMBL2321628 (Hs), CHEMBL3879821 (Mm) |
| Ensembl Gene | ENSG00000184451 (Hs), ENSMUSG00000044052 (Mm), ENSRNOG00000020275 (Rn) |
| Entrez Gene | 2826 (Hs), 12777 (Mm), 363682 (Rn) |
| Human Protein Atlas | ENSG00000184451 (Hs) |
| KEGG Gene | hsa:2826 (Hs), mmu:12777 (Mm), rno:363682 (Rn) |
| OMIM | 600240 (Hs) |
| Pharos | P46092 (Hs) |
| RefSeq Nucleotide | NM_016602 (Hs), NM_007721 (Mm), NM_001108836 (Rn) |
| RefSeq Protein | NP_057686 (Hs), NP_031747 (Mm), NP_001102306 (Rn) |
| UniProtKB | P46092 (Hs), Q9JL21 (Mm) |
| Wikipedia | CCR10 (Hs) |
| Natural/Endogenous Ligands |
| CCL27 {Sp: Human} |
| CCL28 {Sp: Human} |
| CCL27 {Sp: Mouse} |
| CCL28 {Sp: Mouse} |
Download all structure-activity data for this target as a CSV file 
| Agonist Comments | ||
| It has been shown that CCL27 (CTACK/ALP/ILC) [5] and CCL28 (MEC) [13] are both ligands for the CCR10 receptor. |
| Antagonists | ||||||||||||||||||||||||||||||||
| Key to terms and symbols | View all chemical structures | Click column headers to sort | ||||||||||||||||||||||||||||||
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| View species-specific antagonist tables | ||||||||||||||||||||||||||||||||
| Immunopharmacology Comments |
| CCR10 is one of more than 20 distinct chemokine receptors expressed in human leukocytes. Chemokines primarily act to promote leukocyte chemotaxis to sites of inflammation. |
| Immuno Process Associations | |||||||||
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| Primary Transduction Mechanisms
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| Transducer | Effector/Response |
| Gi/Go family | Calcium channel |
| References: | |
| Tissue Distribution
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| Expression Datasets |
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| Functional Assays
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| Physiological Functions
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| Phenotypes, Alleles and Disease Models
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Mouse data from MGI | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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References
1. Abeywardane A, Caviness G, Choi Y, Cogan D, Gao A, Goldberg D, Heim-Riether A, Jeanfavre D, Klein E, Kowalski JA et al.. (2016) N-Arylsulfonyl-α-amino carboxamides are potent and selective inhibitors of the chemokine receptor CCR10 that show efficacy in the murine DNFB model of contact hypersensitivity. Bioorg Med Chem Lett, 26 (21): 5277-5283. [PMID:27692854]
2. Bonini JA, Martin SK, Dralyuk F, Roe MW, Philipson LH, Steiner DF. (1997) Cloning, expression, and chromosomal mapping of a novel human CC-chemokine receptor (CCR10) that displays high-affinity binding for MCP-1 and MCP-3. DNA Cell Biol, 16 (10): 1249-56. [PMID:9364936]
3. Gosling J, Dairaghi DJ, Wang Y, Hanley M, Talbot D, Miao Z, Schall TJ. (2000) Cutting edge: identification of a novel chemokine receptor that binds dendritic cell- and T cell-active chemokines including ELC, SLC, and TECK. J Immunol, 164: 2851-2856. [PMID:10706668]
4. Homey B, Alenius H, Müller A, Soto H, Bowman EP, Yuan W, McEvoy L, Lauerma AI, Assmann T, Bünemann E et al.. (2002) CCL27-CCR10 interactions regulate T cell-mediated skin inflammation. Nat Med, 8 (2): 157-65. [PMID:11821900]
5. Homey B, Wang W, Soto H, Buchanan ME, Wiesenborn A, Catron D, Muller A, McClanahan TK, Dieu-Nosjean MC, Orozco R, Ruzicka T, Lehmann P, Oldham E, Zlotnik A. (2000) Cutting edge: the orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC). J Immunol, 164: 3465-3470. [PMID:10725697]
6. Huber TB, Reinhardt HC, Exner M, Burger JA, Kerjaschki D, Saleem MA, Pavenstädt H. (2002) Expression of functional CCR and CXCR chemokine receptors in podocytes. J Immunol, 168 (12): 6244-52. [PMID:12055238]
7. Jarmin DI, Rits M, Bota D, Gerard NP, Graham GJ, Clark-Lewis I, Gerard C. (2000) Cutting edge: Identification of the orphan receptor G protein-coupled receptor 2 as CCR10, a specific receptor for the chemokine ESkine. J Immunol, 164: 3460-3464. [PMID:10725696]
8. Lüttichau HR, Lewis IC, Gerstoft J, Schwartz TW. (2001) The herpesvirus 8-encoded chemokine vMIP-II, but not the poxvirus-encoded chemokine MC148, inhibits the CCR10 receptor. Eur J Immunol, 31 (4): 1217-20. [PMID:11298347]
9. Marchese A, Docherty JM, Nguyen T, Heiber M, Cheng R, Heng HH, Tsui LC, Shi X, George SR, O'Dowd BF. (1994) Cloning of human genes encoding novel G protein-coupled receptors. Genomics, 23 (3): 609-18. [PMID:7851889]
10. Murakami T, Cardones AR, Finkelstein SE, Restifo NP, Klaunberg BA, Nestle FO, Castillo SS, Dennis PA, Hwang ST. (2003) Immune evasion by murine melanoma mediated through CC chemokine receptor-10. J Exp Med, 198 (9): 1337-47. [PMID:14581607]
11. Soler D, Humphreys TL, Spinola SM, Campbell JJ. (2003) CCR4 versus CCR10 in human cutaneous TH lymphocyte trafficking. Blood, 101 (5): 1677-82. [PMID:12406880]
12. Townson JR, Nibbs RJ. (2002) Characterization of mouse CCX-CKR, a receptor for the lymphocyte-attracting chemokines TECK/mCCL25, SLC/mCCL21 and MIP-3beta/mCCL19: comparison to human CCX-CKR. Eur J Immunol, 32 (5): 1230-41. [PMID:11981810]
13. Wang W, Soto H, Oldham ER, Buchanan ME, Homey B, Catron D, Jenkins N, Copeland NG, Gilbert DJ, Nguyen N et al.. (2000) Identification of a novel chemokine (CCL28), which binds CCR10 (GPR2). J Biol Chem, 275 (29): 22313-23. [PMID:10781587]
How to cite this page
Bachelerie F, Ben-Baruch A, Burkhardt AM, Charo IF, Combadiere C, Farber JM, Förster R, Graham GJ, Hills R, Horuk R, Locati M, Luster AD, Mantovani A, Matsushima K, Monaghan AE, Moschovakis GL, Murphy PM, Nibbs RJB, Nomiyama H, Oppenheim JJ, Power CA, Proudfoot AEI, Rosenkilde MM, Rot A, Sozzani S, Sparre-Ulrich AH, Thelen M, Uddin M, Yoshie O, Zlotnik A. Chemokine receptors in GtoPdb v.2025.1. IUPHAR/BPS Guide to Pharmacology CITE. 2025; 2025(1). Available from: https://doi.org/10.2218/gtopdb/F14/2025.1.
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