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Contents:
- Gene and Protein Information
- Previous and Unofficial Names
- Database Links
- Natural/Endogenous Ligands
- Agonists
- Antagonists
- Immunopharmacology Comments
- Immuno Process Associations
- Transduction Mechanisms
- Tissue Distribution
- Expression Datasets
- Functional Assays
- Physiological Functions
- Physiological Consequences of Altering Gene Expression
- Phenotypes, Alleles and Disease Models
- References
- Contributors
- How to cite this page
Gene and Protein Information  |
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| class A G protein-coupled receptor | ||||||
| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | 7 | 355 | 3p22.1 | CCR8 | C-C motif chemokine receptor 8 | 12,14-15,17-18 |
| Mouse | 7 | 353 | 9 F4 | Ccr8 | C-C motif chemokine receptor 8 | 7 |
| Rat | 7 | - | 8q32 | Ccr8 | C-C motif chemokine receptor 8 | |
| Previous and Unofficial Names |
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| ChemR1 [15] | CKR-L1 [18] | TER1 [11-12] | GPR-CY6 | |
| Database Links |
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| Specialist databases | |
| GPCRdb | ccr8_human (Hs), ccr8_mouse (Mm) |
| Other databases | |
| Alphafold | P51685 (Hs), P56484 (Mm) |
| ChEMBL Target | CHEMBL4596 (Hs), CHEMBL1075278 (Mm) |
| Ensembl Gene | ENSG00000179934 (Hs), ENSMUSG00000042262 (Mm), ENSRNOG00000026759 (Rn) |
| Entrez Gene | 1237 (Hs), 12776 (Mm), 301066 (Rn) |
| Human Protein Atlas | ENSG00000179934 (Hs) |
| KEGG Gene | hsa:1237 (Hs), mmu:12776 (Mm), rno:301066 (Rn) |
| OMIM | 601834 (Hs) |
| Pharos | P51685 (Hs) |
| RefSeq Nucleotide | NM_005201 (Hs), NM_007720 (Mm), XM_236704 (Rn) |
| RefSeq Protein | NP_005192 (Hs), NP_031746 (Mm), XP_236704 (Rn) |
| UniProtKB | P51685 (Hs), P56484 (Mm) |
| Wikipedia | CCR8 (Hs) |
| Natural/Endogenous Ligands |
| CCL1 {Sp: Human} , CCL1 {Sp: Mouse} |
| CCL8 {Sp: Mouse} |
| Comments: CCL1 is the principal endogenous agonist |
Download all structure-activity data for this target as a CSV file 
| Agonists | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Key to terms and symbols | View all chemical structures | Click column headers to sort | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| View species-specific agonist tables | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Antagonists | ||||||||||||||||||||||||||||||||
| Key to terms and symbols | View all chemical structures | Click column headers to sort | ||||||||||||||||||||||||||||||
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| Immunopharmacology Comments |
| CCR8 is one of more than 20 distinct chemokine receptors expressed in human leukocytes. Chemokines primarily act to promote leukocyte chemotaxis to sites of inflammation. |
| Immuno Process Associations | ||||||||||||
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| Primary Transduction Mechanisms
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| Transducer | Effector/Response |
| Gi/Go family | Calcium channel |
| References: 17 | |
| Tissue Distribution
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| Expression Datasets |
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| Functional Assays
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| Physiological Functions
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| Physiological Consequences of Altering Gene Expression
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| Phenotypes, Alleles and Disease Models
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Mouse data from MGI | ||||||||||||||||||||||||
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References
1. Bernardini G, Hedrick J, Sozzani S, Luini W, Spinetti G, Weiss M, Menon S, Zlotnik A, Mantovani A, Santoni A et al.. (1998) Identification of the CC chemokines TARC and macrophage inflammatory protein-1 beta as novel functional ligands for the CCR8 receptor. Eur J Immunol, 28 (2): 582-8. [PMID:9521068]
2. Bernardini G, Spinetti G, Ribatti D, Camarda G, Morbidelli L, Ziche M, Santoni A, Capogrossi MC, Napolitano M. (2000) I-309 binds to and activates endothelial cell functions and acts as an angiogenic molecule in vivo. Blood, 96 (13): 4039-45. [PMID:11110671]
3. Bishop B, Lloyd CM. (2003) CC chemokine ligand 1 promotes recruitment of eosinophils but not Th2 cells during the development of allergic airways disease. J Immunol, 170 (9): 4810-7. [PMID:12707363]
4. Chensue SW, Lukacs NW, Yang TY, Shang X, Frait KA, Kunkel SL, Kung T, Wiekowski MT, Hedrick JA, Cook DN et al.. (2001) Aberrant in vivo T helper type 2 cell response and impaired eosinophil recruitment in CC chemokine receptor 8 knockout mice. J Exp Med, 193 (5): 573-84. [PMID:11238588]
5. Dairaghi DJ, Fan RA, McMaster BE, Hanley MR, Schall TJ. (1999) HHV8-encoded vMIP-I selectively engages chemokine receptor CCR8. Agonist and antagonist profiles of viral chemokines. J Biol Chem, 274 (31): 21569-74. [PMID:10419462]
6. Freeman CM, Chiu BC, Stolberg VR, Hu J, Zeibecoglou K, Lukacs NW, Lira SA, Kunkel SL, Chensue SW. (2005) CCR8 is expressed by antigen-elicited, IL-10-producing CD4+CD25+ T cells, which regulate Th2-mediated granuloma formation in mice. J Immunol, 174 (4): 1962-70. [PMID:15699124]
7. Goya I, Gutiérrez J, Varona R, Kremer L, Zaballos A, Márquez G. (1998) Identification of CCR8 as the specific receptor for the human beta-chemokine I-309: cloning and molecular characterization of murine CCR8 as the receptor for TCA-3. J Immunol, 160 (4): 1975-81. [PMID:9469461]
8. Haskell CA, Horuk R, Liang M, Rosser M, Dunning L, Islam I, Kremer L, Gutiérrez J, Marquez G, Martinez-A C et al.. (2006) Identification and characterization of a potent, selective nonpeptide agonist of the CC chemokine receptor CCR8. Mol Pharmacol, 69 (1): 309-16. [PMID:16221874]
9. Huber TB, Reinhardt HC, Exner M, Burger JA, Kerjaschki D, Saleem MA, Pavenstädt H. (2002) Expression of functional CCR and CXCR chemokine receptors in podocytes. J Immunol, 168 (12): 6244-52. [PMID:12055238]
10. Inngjerdingen M, Damaj B, Maghazachi AA. (2001) Expression and regulation of chemokine receptors in human natural killer cells. Blood, 97 (2): 367-75. [PMID:11154210]
11. Jinno A, Shimizu N, Soda Y, Haraguchi Y, Kitamura T, Hoshino H. (1998) Identification of the chemokine receptor TER1/CCR8 expressed in brain-derived cells and T cells as a new coreceptor for HIV-1 infection. Biochem Biophys Res Commun, 243 (2): 497-502. [PMID:9480837]
12. Napolitano M, Zingoni A, Bernardini G, Spinetti G, Nista A, Storlazzi CT, Rocchi M, Santoni A. (1996) Molecular cloning of TER1, a chemokine receptor-like gene expressed by lymphoid tissues. J Immunol, 157: 2759-2763. [PMID:8816377]
13. Qu C, Edwards EW, Tacke F, Angeli V, Llodrá J, Sanchez-Schmitz G, Garin A, Haque NS, Peters W, van Rooijen N et al.. (2004) Role of CCR8 and other chemokine pathways in the migration of monocyte-derived dendritic cells to lymph nodes. J Exp Med, 200 (10): 1231-41. [PMID:15534368]
14. Roos RS, Loetscher M, Legler DF, Clark-Lewis I, Baggiolini M, Moser B. (1997) Identification of CCR8, the receptor for the human CC chemokine I-309. J Biol Chem, 272 (28): 17251-4. [PMID:9211859]
15. Samson M, Stordeur P, Labbé O, Soularue P, Vassart G, Parmentier M. (1996) Molecular cloning and chromosomal mapping of a novel human gene, ChemR1, expressed in T lymphocytes and polymorphonuclear cells and encoding a putative chemokine receptor. Eur J Immunol, 26 (12): 3021-8. [PMID:8977299]
16. Spinetti G, Bernardini G, Camarda G, Mangoni A, Santoni A, Capogrossi MC, Napolitano M. (2003) The chemokine receptor CCR8 mediates rescue from dexamethasone-induced apoptosis via an ERK-dependent pathway. J Leukoc Biol, 73: 201-207. [PMID:12525579]
17. Tiffany HL, Lautens LL, Gao JL, Pease J, Locati M, Combadiere C, Modi W, Bonner TI, Murphy PM. (1997) Identification of CCR8: a human monocyte and thymus receptor for the CC chemokine I-309. J Exp Med, 186 (1): 165-70. [PMID:9207005]
18. Zaballos A, Varona R, Gutierrez J, Lind P, Marquez G. (1996) Molecular cloning and RNA expression of two new human chemokine receptor-like genes. Biochem Biophys Res Commun, 227: 846-853. [PMID:8886020]
How to cite this page
Bachelerie F, Ben-Baruch A, Burkhardt AM, Charo IF, Combadiere C, Farber JM, Förster R, Graham GJ, Hills R, Horuk R, Locati M, Luster AD, Mantovani A, Matsushima K, Monaghan AE, Moschovakis GL, Murphy PM, Nibbs RJB, Nomiyama H, Oppenheim JJ, Power CA, Proudfoot AEI, Rosenkilde MM, Rot A, Sozzani S, Sparre-Ulrich AH, Thelen M, Uddin M, Yoshie O, Zlotnik A. Chemokine receptors in GtoPdb v.2025.1. IUPHAR/BPS Guide to Pharmacology CITE. 2025; 2025(1). Available from: https://doi.org/10.2218/gtopdb/F14/2025.1.
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