isopentenyl-diphosphate Δ-isomerase 2 | Lanosterol biosynthesis pathway | IUPHAR/MMV Guide to MALARIA PHARMACOLOGY

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isopentenyl-diphosphate Δ-isomerase 2

Target id: 647

Nomenclature: isopentenyl-diphosphate Δ-isomerase 2

Family: Lanosterol biosynthesis pathway

Annotation status:  image of an orange circle Annotated and awaiting review. Please contact us if you can help with reviewing.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 227 10p15.3 IDI2 isopentenyl-diphosphate delta isomerase 2 4
Mouse - 227 13 A1; 13 Idi2 isopentenyl-diphosphate delta isomerase 2
Rat - 227 17q12.1 Idi2 isopentenyl-diphosphate delta isomerase 2
Previous and Unofficial Names
IPPI2 | isopentenyl-diphosphate delta isomerase 2 | IPP isomerase 2 | isopentenyl pyrophosphate isomerase 2
Database Links
BRENDA
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Selected 3D Structures
Image of receptor 3D structure from RCSB PDB
Description:  Structure of Human Isopentenyl-diphosphate Delta-isomerase 2
PDB Id:  2PNY
Resolution:  1.81Å
Species:  Human
References: 
Enzyme Reaction
EC Number: 5.3.3.2 Isopentenyl diphosphate = dimethylallyl diphosphate
Cofactors
Cofactor Species Comments Reference
Mg2+ Human Enzyme activity increases with increasing Mg2+ up to 20mM. 3,5
Mn2+ Human Activity increases up to a concentration of 100 micromolar Mn2+ then sharply decreases. 2-3
Tissue Distribution Comments
Highly expressed in skeletal muscle [1-2].

References

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1. Breitling R, Laubner D, Clizbe D, Adamski J, Krisans SK. (2003) Isopentenyl-diphosphate isomerases in human and mouse: evolutionary analysis of a mammalian gene duplication. J. Mol. Evol., 57 (3): 282-91. [PMID:14629038]

2. Clizbe DB, Owens ML, Masuda KR, Shackelford JE, Krisans SK. (2007) IDI2, a second isopentenyl diphosphate isomerase in mammals. J. Biol. Chem., 282 (9): 6668-76. [PMID:17202134]

3. Hahn FM, Xuan JW, Chambers AF, Poulter CD. (1996) Human isopentenyl diphosphate: dimethylallyl diphosphate isomerase: overproduction, purification, and characterization. Arch. Biochem. Biophys., 332 (1): 30-4. [PMID:8806705]

4. Kato T, Emi M, Sato H, Arawaka S, Wada M, Kawanami T, Katagiri T, Tsuburaya K, Toyoshima I, Tanaka F et al.. (2010) Segmental copy-number gain within the region of isopentenyl diphosphate isomerase genes in sporadic amyotrophic lateral sclerosis. Biochem. Biophys. Res. Commun., 402 (2): 438-42. [PMID:20955688]

5. Zhang C, Liu L, Xu H, Wei Z, Wang Y, Lin Y, Gong W. (2007) Crystal structures of human IPP isomerase: new insights into the catalytic mechanism. J. Mol. Biol., 366 (5): 1437-46. [PMID:17137593]

Contributors

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