isopentenyl-diphosphate Δ-isomerase 2 | Lanosterol biosynthesis pathway | IUPHAR/MMV Guide to MALARIA PHARMACOLOGY

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isopentenyl-diphosphate Δ-isomerase 2

Target id: 647

Nomenclature: isopentenyl-diphosphate Δ-isomerase 2

Family: Lanosterol biosynthesis pathway

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 227 10p15.3 IDI2 isopentenyl-diphosphate delta isomerase 2 4
Mouse - 227 13 A1; 13 Idi2 isopentenyl-diphosphate delta isomerase 2
Rat - 227 17q12.1 Idi2 isopentenyl-diphosphate delta isomerase 2
Previous and Unofficial Names
IPPI2 | isopentenyl-diphosphate delta isomerase 2 | IPP isomerase 2 | isopentenyl pyrophosphate isomerase 2
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Selected 3D Structures
Image of receptor 3D structure from RCSB PDB
Description:  Structure of Human Isopentenyl-diphosphate Delta-isomerase 2
Resolution:  1.81Å
Species:  Human
Enzyme Reaction
EC Number: Isopentenyl diphosphate = dimethylallyl diphosphate
Cofactor Species Comments Reference
Mg2+ Human Enzyme activity increases with increasing Mg2+ up to 20mM. 3,5
Mn2+ Human Activity increases up to a concentration of 100 micromolar Mn2+ then sharply decreases. 2-3
Tissue Distribution Comments
Highly expressed in skeletal muscle [1-2].


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1. Breitling R, Laubner D, Clizbe D, Adamski J, Krisans SK. (2003) Isopentenyl-diphosphate isomerases in human and mouse: evolutionary analysis of a mammalian gene duplication. J. Mol. Evol., 57 (3): 282-91. [PMID:14629038]

2. Clizbe DB, Owens ML, Masuda KR, Shackelford JE, Krisans SK. (2007) IDI2, a second isopentenyl diphosphate isomerase in mammals. J. Biol. Chem., 282 (9): 6668-76. [PMID:17202134]

3. Hahn FM, Xuan JW, Chambers AF, Poulter CD. (1996) Human isopentenyl diphosphate: dimethylallyl diphosphate isomerase: overproduction, purification, and characterization. Arch. Biochem. Biophys., 332 (1): 30-4. [PMID:8806705]

4. Kato T, Emi M, Sato H, Arawaka S, Wada M, Kawanami T, Katagiri T, Tsuburaya K, Toyoshima I, Tanaka F et al.. (2010) Segmental copy-number gain within the region of isopentenyl diphosphate isomerase genes in sporadic amyotrophic lateral sclerosis. Biochem. Biophys. Res. Commun., 402 (2): 438-42. [PMID:20955688]

5. Zhang C, Liu L, Xu H, Wei Z, Wang Y, Lin Y, Gong W. (2007) Crystal structures of human IPP isomerase: new insights into the catalytic mechanism. J. Mol. Biol., 366 (5): 1437-46. [PMID:17137593]


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