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isopentenyl-diphosphate Δ-isomerase 2

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Target id: 647

Nomenclature: isopentenyl-diphosphate Δ-isomerase 2

Family: Lanosterol biosynthesis pathway

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 227 10p15.3 IDI2 isopentenyl-diphosphate delta isomerase 2 4
Mouse - 227 13 A1 Idi2 isopentenyl-diphosphate delta isomerase 2
Rat - 227 17q12.1 Idi2 isopentenyl-diphosphate delta isomerase 2
Previous and Unofficial Names Click here for help
IPPI2 | isopentenyl-diphosphate delta isomerase 2 | IPP isomerase 2 | isopentenyl pyrophosphate isomerase 2
Database Links Click here for help
Alphafold Q9BXS1 (Hs), Q8BFZ6 (Mm)
BRENDA 5.3.3.2
Ensembl Gene ENSG00000148377 (Hs), ENSMUSG00000033520 (Mm), ENSRNOG00000069625 (Rn)
Entrez Gene 91734 (Hs), 320581 (Mm), 502143 (Rn)
Human Protein Atlas ENSG00000148377 (Hs)
KEGG Enzyme 5.3.3.2
KEGG Gene hsa:91734 (Hs), mmu:320581 (Mm), rno:502143 (Rn)
OMIM 615389 (Hs)
Pharos Q9BXS1 (Hs)
RefSeq Nucleotide NM_033261 (Hs), NM_177197 (Mm), NM_001192008 (Rn)
RefSeq Protein NP_150286 (Hs), NP_796171 (Mm), NP_001178937 (Rn)
UniProtKB Q9BXS1 (Hs), Q8BFZ6 (Mm)
Wikipedia IDI2 (Hs)
Selected 3D Structures Click here for help
Image of receptor 3D structure from RCSB PDB
Description:  Structure of Human Isopentenyl-diphosphate Delta-isomerase 2
PDB Id:  2PNY
Resolution:  1.81Å
Species:  Human
References: 
Enzyme Reaction Click here for help
EC Number: 5.3.3.2 Isopentenyl diphosphate = dimethylallyl diphosphate
Cofactors Click here for help
Cofactor Species Comments Reference
Mg2+ Human Enzyme activity increases with increasing Mg2+ up to 20mM. 3,5
Mn2+ Human Activity increases up to a concentration of 100 micromolar Mn2+ then sharply decreases. 2-3
Tissue Distribution Comments
Highly expressed in skeletal muscle [1-2].

References

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1. Breitling R, Laubner D, Clizbe D, Adamski J, Krisans SK. (2003) Isopentenyl-diphosphate isomerases in human and mouse: evolutionary analysis of a mammalian gene duplication. J Mol Evol, 57 (3): 282-91. [PMID:14629038]

2. Clizbe DB, Owens ML, Masuda KR, Shackelford JE, Krisans SK. (2007) IDI2, a second isopentenyl diphosphate isomerase in mammals. J Biol Chem, 282 (9): 6668-76. [PMID:17202134]

3. Hahn FM, Xuan JW, Chambers AF, Poulter CD. (1996) Human isopentenyl diphosphate: dimethylallyl diphosphate isomerase: overproduction, purification, and characterization. Arch Biochem Biophys, 332 (1): 30-4. [PMID:8806705]

4. Kato T, Emi M, Sato H, Arawaka S, Wada M, Kawanami T, Katagiri T, Tsuburaya K, Toyoshima I, Tanaka F et al.. (2010) Segmental copy-number gain within the region of isopentenyl diphosphate isomerase genes in sporadic amyotrophic lateral sclerosis. Biochem Biophys Res Commun, 402 (2): 438-42. [PMID:20955688]

5. Zhang C, Liu L, Xu H, Wei Z, Wang Y, Lin Y, Gong W. (2007) Crystal structures of human IPP isomerase: new insights into the catalytic mechanism. J Mol Biol, 366 (5): 1437-46. [PMID:17137593]

Contributors

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