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Neuropilins and Plexins

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Neuropilins act as receptors for class 3 (secreted) semaphorins; Plexins are receptors for class 4, 5 and 6 (transmembrane) semaphorins and are signalling partners for class 3 semaphorins. The semaphorins and their receptors participate in numerous and diverse biological processes including neural development, immunology/inflammation, cardiac growth, vascular development, lung morphogenesis, and axial bone patterning.

Targets

3299
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neuropilin 1 Show summary » More detailed page go icon to follow link

plexin D1 Show summary »

Target Id 3299
Nomenclature plexin D1
Genes PLXND1 (Hs), Plxnd1 (Mm), Plxnd1 (Rn)
Ensembl ID ENSG00000004399 (Hs), ENSMUSG00000030123 (Mm), ENSRNOG00000025209 (Rn)
UniProtKB AC Q9Y4D7 (Hs), Q3UH93 (Mm)
Inhibitors
D1SP [1]
Comment PlexinD1 is a semaphorin receptor that participates in axon guidance. Upregulation of PlexinD1 expression (and of its ligands Sema3E and Sema3C) acts to drive aggressiveness, invasiveness, and drug resistance in metastatic prostate cancer cells [1]. A synthetic PlexinD1:Fc decoy fusion protein (D1SP) has been demonstrated to suppress prostate cancer proliferation in preclinical models.

References

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How to cite this family page

Database page citation:

Neuropilins and Plexins. Accessed on 28/04/2025. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=991.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Buneman OP, Faccenda E, Harding SD, Spedding M, Cidlowski JA, Fabbro D, Davenport AP, Striessnig J, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Introduction and Other Protein Targets. Br J Pharmacol. 180 Suppl 2:S1-22.