Zinc finger TFs

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The WIZ transcription factor is involved in regulating trancriptional activity via modulating interactions with DNA-binding transcription factors and transcription corepressors. It is also a component of the G9A (EHMT2)/GLP (EHMT1) H3K9 methyltransferase complex. WIZ participates in repression of fetal hemoglobin (HbF) expression. Targeted degradation of WIZ protein is being explored as a mechanism to reactivate HbF expression as a therapy for Sickle cell disease [1].

Targets

3294

WIZ zinc finger Show summary »« Hide summary

Target Id

3294

Nomenclature

WIZ zinc finger

Previous and unofficial names

widely interspaced zinc finger motifs | ZNF803 | Widely-interspaced zinc finger-containing protein | zinc finger protein 803

Genes

WIZ (Hs), Wiz (Mm), Wiz (Rn)

Ensembl ID

ENSG00000011451 (Hs), ENSMUSG00000024050 (Mm), ENSRNOG00000006217 (Rn)

UniProtKB AC

O95785 (Hs), O88286 (Mm)

Ligands

dWIZ-1 (Binding) (molecular glue degrader) [1]

Comment

The WIZ protein is a chromatin-associated transcription factor that localizes to promoters and enhancers. Evidence supports WIZ as a putative fetal hemoglobin (HbF) gene control factor that represses HbF expression. Targeted WIZ depletion is being explored as a mechanism to re-activate HbF expression, as a strategy to treat Sickle cell disease [1].

References

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How to cite this family page

Database page citation:

Zinc finger TFs. Accessed on 28/04/2025. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=1102.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Buneman OP, Faccenda E, Harding SD, Spedding M, Cidlowski JA, Fabbro D, Davenport AP, Striessnig J, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Introduction and Other Protein Targets. Br J Pharmacol. 180 Suppl 2:S1-22.