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Methyllysine reader proteins C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Methyllysine reader proteins bind to methylated proteins, such as histones, allowing regulation of gene expression.

Targets

3274
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L3MBTL histone methyl-lysine binding protein 3 C Show summary » More detailed page go icon to follow link

spindlin 1 Show summary »

Target Id 3274
Nomenclature spindlin 1
Previous and unofficial names TDRD24
Genes SPIN1 (Hs), Spin1 (Mm), Spin1 (Rn)
Ensembl ID ENSG00000106723 (Hs), ENSMUSG00000021395 (Mm), ENSRNOG00000067284 (Rn)
UniProtKB AC Q9Y657 (Hs), Q3TLC3 (Mm), Q4V8J7 (Rn)
Inhibitors
MS8535 (Binding) pKd 7.5 [3]
MS31 (Binding) pKd 7.0
MS31 pIC50 7.1 [2]
MS8535 pIC50 6.7 [3]
Comment The SPIN1 gene encodes the spindlin 1 methyl-lysine reader protein. It recognises dimethylated histone H3 arginine 8 (H3R8me2a) and trimethylated histone H3 lysine 4 (H3K4me3) modifications and acts as a transcriptional coactivator. It has non-reader functions including roles in spindle stability maintenance and chromosome segregation. SPIN1 is overexpressed in several types of malignancies, making it a target for anti-cancer drug development.

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References

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How to cite this family page

Database page citation:

Methyllysine reader proteins. Accessed on 28/04/2025. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=902.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Buneman OP, Faccenda E, Harding SD, Spedding M, Cidlowski JA, Fabbro D, Davenport AP, Striessnig J, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Introduction and Other Protein Targets. Br J Pharmacol. 180 Suppl 2:S1-22.