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Plasmodium falciparum bifunctional farnesyl/geranylgeranyl diphosphate synthase

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Target id: 3173

Nomenclature: Plasmodium falciparum bifunctional farnesyl/geranylgeranyl diphosphate synthase

Abbreviated Name: PfFPPS/GGPPS

Family: Other antimalarial targets

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Plasmodium falciparum 3D7 - 376 FPPS/GGPPS bifunctional farnesyl/geranylgeranyl diphosphate synthase
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PlasmoDB
UniProtKB
Whole Organism Assay Data Linked to This Target
Key to terms and symbols Click column headers to sort
Ligand Sp. Assay description Type Action Value Parameter Reference
MMV019313 Small molecule or natural product PfDd2 - - 6.7 pEC50 1
pEC50 6.7 (EC50 1.8x10-7 M) [1]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
MMV019313 Small molecule or natural product PfW2 - - 6.6 pEC50 1
pEC50 6.6 (EC50 2.7x10-7 M) [1]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)

References

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1. Gisselberg JE, Herrera Z, Orchard LM, Llinás M, Yeh E. (2018) Specific Inhibition of the Bifunctional Farnesyl/Geranylgeranyl Diphosphate Synthase in Malaria Parasites via a New Small-Molecule Binding Site. Cell Chem Biol, 25 (2): 185-193.e5. [PMID:29276048]

How to cite this page

Other antimalarial targets: Plasmodium falciparum bifunctional farnesyl/geranylgeranyl diphosphate synthase. Last modified on 16/03/2021. Accessed on 14/05/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=3173.