Contents:
Gene and Protein Information  |
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| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| SARS-CoV-2 | 1 | 43 | ORF7b | Non-structural protein 7b | ||
| SARS-CoV | 1 | 44 | Orf7b | Non-structural protein 7b | ||
| Previous and Unofficial Names |
| Accessory protein 7b | nsp7b |
| Database Links |
|
| Entrez Gene | 43740578 (SARS-CoV-2), 1489675 (SARS-CoV) |
| RefSeq Protein | YP_009825058 (SARS-CoV), YP_009725318 (SARS-CoV-2) |
| UniProtKB | P0DTD8 (SARS-CoV-2), Q7TFA1 (SARS-CoV) |
| General Comments |
| Protein 7b is a coronavirus accessory protein. It is a single-pass transmembrane protein. Investigations using a naturally occurring variant of SARS-CoV with a deletion in protein 7b (Frankfurt-1 strain) suggests that 7b has some attenuating function during the early phase of infection [1]. The deletion variant conferred increased virulence but did not alter infection capacity. By homology, SARS-CoV-2 7b is likely to have a similar function. |
References
1. Pfefferle S, Krähling V, Ditt V, Grywna K, Mühlberger E, Drosten C. (2009) Reverse genetic characterization of the natural genomic deletion in SARS-Coronavirus strain Frankfurt-1 open reading frame 7b reveals an attenuating function of the 7b protein in-vitro and in-vivo. Virol J, 6: 131. [PMID:19698190]
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