Plasmodium falciparum cytochrome b | Antimalarial targets | IUPHAR/MMV Guide to MALARIA PHARMACOLOGY

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Plasmodium falciparum cytochrome b

Target id: 3087

Nomenclature: Plasmodium falciparum cytochrome b

Abbreviated Name: PfCYTB

Family: Antimalarial targets

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Plasmodium falciparum 3D7 - 376 CYTB
Database Links
PlasmoDB
UniProtKB
Whole Organism Assay Data Linked to This Target
Key to terms and symbols Click column headers to sort
Ligand Sp. Assay description Type Action Value Parameter Reference
ELQ-300 Pb Parasite liver stage assay - - 9.0 pEC50 2
pEC50 9.0 (EC50 1.02x10-9 M) Luciferase bioluminescence assay to measure viability of exoerythrocytic forms [2]
Lifecycle stages: Plasmodium liver stage (sporozoite, hepatic schizont, hepatic merozoite)
atovaquone PfD6 Parasite growth inhibition assay - - 10.0 pIC50 1
pIC50 10.0 (IC50 1x10-10 M) [3H]-hypoxanthine incorporation [1]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
atovaquone PfW2 Parasite growth inhibition assay - - 9.7 pIC50 1
pIC50 9.7 (IC50 2x10-10 M) [3H]-hypoxanthine incorporation [1]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
atovaquone Pf7G8 Parasite growth inhibition assay - - 9.5 pIC50 1
pIC50 9.5 (IC50 3x10-10 M) [3H]-hypoxanthine incorporation [1]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
atovaquone PfTM90C2A Parasite growth inhibition assay - - 9.3 pIC50 1
pIC50 9.3 (IC50 5x10-10 M) [3H]-hypoxanthine incorporation [1]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
atovaquone PfNF54 Parasite growth inhibition assay - - 9.2 pIC50 1
pIC50 9.2 (IC50 6x10-10 M) [3H]-hypoxanthine incorporation [1]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
atovaquone PfK1 Parasite growth inhibition assay - - 9.0 pIC50 1
pIC50 9.0 (IC50 1.1x10-9 M) [3H]-hypoxanthine incorporation [1]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
atovaquone PfV1/S Parasite growth inhibition assay - - 8.9 pIC50 1
pIC50 8.9 (IC50 1.4x10-9 M) [3H]-hypoxanthine incorporation [1]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
ELQ-300 PfW2 Parasite growth inhibition assay - - 8.6 – 8.7 pIC50 2
pIC50 8.7 (IC50 1.8x10-9 M) SYBR green method, measured at 72h [2]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
pIC50 8.6 (IC50 2.27x10-9 M) [3H]-hypoxanthine incorporation [2]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
ELQ-300 PfTM90C2B Parasite growth inhibition assay - - 8.6 – 8.8 pIC50 2
pIC50 8.8 (IC50 1.7x10-9 M) SYBR green method, measured at 72h [2]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
pIC50 8.6 (IC50 2.84x10-9 M) [3H]-hypoxanthine incorporation [2]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
ELQ-300 PfDd2 Parasite growth inhibition assay - - 8.6 pIC50 2
pIC50 8.6 (IC50 2.5x10-9 M) SYBR green method, measured at 72h [2]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
ELQ-300 PfD6 Parasite growth inhibition assay - - 8.5 – 8.7 pIC50 2
pIC50 8.7 (IC50 2.2x10-9 M) SYBR green method, measured at 72h [2]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
pIC50 8.5 (IC50 3.06x10-9 M) [3H]-hypoxanthine incorporation [2]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
ELQ-300 PfTM91C235 Parasite growth inhibition assay - - 8.4 pIC50 2
pIC50 8.4 (IC50 4.34x10-9 M) [3H]-hypoxanthine incorporation [2]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
ELQ-300 PfNF54 Parasite late stage (IV–V) gametocyte assay - - 7.1 pIC50 2
pIC50 7.1 (IC50 7.19x10-8 M) High-content fluorescence-based image analysis of gametocyte viability throughout a period of 72 hours [2]
Lifecycle stages: Plasmodium sexual blood stage (gametocyte)
ELQ-300 Pc Parasite liver stage assay - - ~7.0 pIC50 2
pIC50 ~7.0 (IC50 ~1x10-7 M) High-content fluorescence imaging to quantify the number of developing hepatic schizonts in primary rhesus hepatocytes infected with sporozoites from the M strain of P. cynomolgi [2]
Lifecycle stages: Plasmodium liver stage (sporozoite, hepatic schizont, hepatic merozoite)
ELQ-300 PfNF54 Parasite early stage (I–III) gametocyte assay - - - - 2
Giemsa-stained blood film counts: treated gametocytes did not develop past stage III, even at 0.1 μM, the lowest dose tested [2]
Lifecycle stages: Plasmodium sexual blood stage (gametocyte)

References

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1. Delves M, Plouffe D, Scheurer C, Meister S, Wittlin S, Winzeler EA, Sinden RE, Leroy D. (2012) The activities of current antimalarial drugs on the life cycle stages of Plasmodium: a comparative study with human and rodent parasites. PLoS Med., 9 (2): e1001169. [PMID:22363211]

2. Nilsen A, LaCrue AN, White KL, Forquer IP, Cross RM, Marfurt J, Mather MW, Delves MJ, Shackleford DM, Saenz FE et al.. (2013) Quinolone-3-diarylethers: a new class of antimalarial drug. Sci Transl Med, 5 (177): 177ra37. [PMID:23515079]

How to cite this page

Antimalarial targets: Plasmodium falciparum cytochrome b. Last modified on 18/06/2019. Accessed on 19/11/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=3087.