Plasmodium falciparum cleavage and polyadenylation specificity factor subunit 3 | Antimalarial targets | IUPHAR/MMV Guide to MALARIA PHARMACOLOGY

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Plasmodium falciparum cleavage and polyadenylation specificity factor subunit 3

Target id: 3076

Nomenclature: Plasmodium falciparum cleavage and polyadenylation specificity factor subunit 3

Abbreviated Name: PfCPSF3

Family: Antimalarial targets

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Plasmodium falciparum 3D7 - 876 CPSF3 cleavage and polyadenylation specificity factor subunit 3, putative
Previous and Unofficial Names
PfCPSF73 | PfCPSF-73
Database Links
UniProtKB
Whole Organism Assay Data Linked to This Target
Key to terms and symbols Click column headers to sort
Ligand Sp. Assay description Type Action Value Parameter Reference
AN3661 PfK1 Parasite growth inhibition assay - - 7.7 pIC50 2
pIC50 7.7 (IC50 2x10-8 M) [3H]-hypoxanthine incorporation [2]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
AN3661 PfFCR3 Parasite growth inhibition assay - - 7.5 pIC50 2
pIC50 7.5 (IC50 3x10-8 M) [3H]-hypoxanthine incorporation [2]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
AN3661 PfDd2 Parasite growth inhibition assay - - 7.4 pIC50 2
pIC50 7.4 (IC50 3.9x10-8 M) [3H]-hypoxanthine incorporation [2]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
AN3661 Pf3D7 Parasite growth inhibition assay - - 7.3 pIC50 2
pIC50 7.3 (IC50 5.2x10-8 M) [3H]-hypoxanthine incorporation [2]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
AN3661 PfHB3 Parasite growth inhibition assay - - 7.3 pIC50 2
pIC50 7.3 (IC50 5.6x10-8 M) [3H]-hypoxanthine incorporation [2]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Malaria Pharmacology Comments
Cleavage and Polyadenylation Specificity Factor subunit 3 (CPSF3 or CPSF73) is a 73kDa subunit of the CPSF protein complex. This complex directs the 3' cleavage and polyadenylation reaction that is an essential step in eukaryotic mRNA processing. CPSF3 is a zinc-dependent endonuclease that cleaves the mRNA precursor downstream of the polyadenylation signal sequence [1].
P. falciparum CPSF3 (PfCPSF3) has been identified as a possible target for the benzoxaborole hit compound AN3661 and may have potential as a target for antimalarial drug development [2].

References

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1. Mandel CR, Kaneko S, Zhang H, Gebauer D, Vethantham V, Manley JL, Tong L. (2006) Polyadenylation factor CPSF-73 is the pre-mRNA 3'-end-processing endonuclease. Nature, 444 (7121): 953-6. [PMID:17128255]

2. Sonoiki E, Ng CL, Lee MC, Guo D, Zhang YK, Zhou Y, Alley MR, Ahyong V, Sanz LM, Lafuente-Monasterio MJ et al.. (2017) A potent antimalarial benzoxaborole targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue. Nat Commun, 8: 14574. [PMID:28262680]

How to cite this page

Antimalarial targets: Plasmodium falciparum cleavage and polyadenylation specificity factor subunit 3. Last modified on 20/03/2019. Accessed on 21/10/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=3076.