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Target id: 3075
Nomenclature: Plasmodium falciparum GPI-anchored wall transfer protein 1
Abbreviated Name: PfGWT1
Family: Antimalarial targets
Gene and Protein Information ![]() |
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Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Plasmodium falciparum 3D7 | - | 874 | GWT1 | GPI-anchored wall transfer protein 1, putative |
Database Links ![]() |
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PlasmoDB | PF3D7_0615300 (Pf3D7) |
UniProtKB | C6KSZ4 (Pf3D7) |
Malaria Pharmacology Comments |
GWT1 (PfGWT1), one of the essential enzymes involved in GPI biosynthesis in the malaria parasite P. falciparum, is a promising novel target for antimalarial drug development (Patent WO2004048567 [1]). In this patent representative compounds known to inhibit yeast GWT1 were assayed for antimalarial activity, with compound 3 (PubChem CID 9860834) reported to have the most potent activity. |
1. Hata K, Ogawa K, Tsukada I, Nakamoto K, Sagane K, Tanaka K, Tsukahara K, Horii T. (2004) Methods of screening for compounds that inhibit the biosynthesis of GPI in malaria parasites. Patent number: WO2004048567A2. Assignee: Eisai Co., Ltd. Priority date: 22/11/2002. Publication date: 10/06/2004.
Antimalarial targets: Plasmodium falciparum GPI-anchored wall transfer protein 1. Last modified on 10/07/2019. Accessed on 20/01/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=3075.