Plasmodium falciparum GPI-anchored wall transfer protein 1 | Antimalarial targets | IUPHAR/MMV Guide to MALARIA PHARMACOLOGY

Top ▲

Plasmodium falciparum GPI-anchored wall transfer protein 1

Target id: 3075

Nomenclature: Plasmodium falciparum GPI-anchored wall transfer protein 1

Abbreviated Name: PfGWT1

Family: Antimalarial targets

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Plasmodium falciparum 3D7 - 874 GWT1 GPI-anchored wall transfer protein 1, putative
Database Links
UniProtKB
Malaria Pharmacology Comments
GWT1 (PfGWT1), one of the essential enzymes involved in GPI biosynthesis in the malaria parasite P. falciparum, is a promising novel target for antimalarial drug development (Patent WO2004048567 [1]). In this patent representative compounds known to inhibit yeast GWT1 were assayed for antimalarial activity, with compound 3 (PubChem CID 9860834) reported to have the most potent activity.

References

Show »

1. Hata K, Ogawa K, Tsukada I, Nakamoto K, Sagane K, Tanaka K, Tsukahara K, Horii T. (2004) Methods of screening for compounds that inhibit the biosynthesis of GPI in malaria parasites. Patent number: WO2004048567A2. Assignee: Eisai Co., Ltd. Priority date: 22/11/2002. Publication date: 10/06/2004.

How to cite this page

Antimalarial targets: Plasmodium falciparum GPI-anchored wall transfer protein 1. Last modified on 10/07/2019. Accessed on 21/10/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=3075.