| This is beta-release v2.0 of the GtoMPdb. It contains the majority of features and functionality expected in the full public release. However, it remains under development and while it should not contain any critical bugs, some portions are not yet optimised and may lack full functionality or content. | Report a bug |
Plasmodium falciparum GPI-anchored wall transfer protein 1
Target id: 3075
Nomenclature: Plasmodium falciparum GPI-anchored wall transfer protein 1
Abbreviated Name: PfGWT1
Family: Antimalarial targets
Annotation status:
Awaiting annotation/under development. Please contact us if you can help with annotation.
» Email us
Contents:
Gene and Protein Information  |
||||||
| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Plasmodium falciparum 3D7 | - | 874 | GWT1 | GPI-anchored wall transfer protein 1, putative | ||
| Database Links |
|
| UniProtKB | C6KSZ4 (Pf3D7) |
| Malaria Pharmacology Comments |
| GWT1 (PfGWT1), one of the essential enzymes involved in GPI biosynthesis in the malaria parasite P. falciparum, is a promising novel target for antimalarial drug development (Patent WO2004048567A2 [1]). In this patent representative compounds known to inhibit yeast GWT1 were assayed for antimalarial activity, with compound 3 (PubChem CID 9860834) reported to have the most potent activity. |
References
1. Hata K, Ogawa K, Tsukada I, Nakamoto K, Sagane K, Tanaka K, Tsukahara K, Horii T. (2004) Methods of screening for compounds that inhibit the biosynthesis of GPI in malaria parasites. Patent number: WO2004048567. Assignee: Eisai Co., Ltd. Priority date: 22/11/2002. Publication date: 10/06/2004.
How to cite this page
Antimalarial targets: Plasmodium falciparum GPI-anchored wall transfer protein 1. Last modified on 25/03/2019. Accessed on 18/08/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=3075.
