Plasmodium falciparum phosphatidylinositol 3-kinase | Antimalarial targets | IUPHAR/MMV Guide to MALARIA PHARMACOLOGY

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Plasmodium falciparum phosphatidylinositol 3-kinase

Target id: 3073

Nomenclature: Plasmodium falciparum phosphatidylinositol 3-kinase

Abbreviated Name: PfPI3K

Family: Antimalarial targets

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Plasmodium falciparum 3D7 - 2133 PI3K phosphatidylinositol 3-kinase
Previous and Unofficial Names
PfVPS34
Database Links
UniProtKB
Malaria Pharmacology Comments
P. falciparum phosphatidylinositol 3-kinase (PfPI3K) is the only PI3K that has been identified in the parasite's genome, with sequence analysis and domain organization suggesting that it may be closest to class III PI3Ks, such as VPS34 [1]. The same study found that PfPI3K is involved in endocytosis from the host and trafficking of haemoglobin in the parasite, with inhibition of PI3K causing accumulation of uncatabolized haemoglobin.
The PI3K inhibitors wortmannin and LY 294002 have been shown to be effective against PfPI3K [1] but selectivity at the Plasmodium target is likely to be a key issue.

References

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1. Vaid A, Ranjan R, Smythe WA, Hoppe HC, Sharma P. (2010) PfPI3K, a phosphatidylinositol-3 kinase from Plasmodium falciparum, is exported to the host erythrocyte and is involved in hemoglobin trafficking. Blood, 115 (12): 2500-7. [PMID:20093402]

How to cite this page

Antimalarial targets: Plasmodium falciparum phosphatidylinositol 3-kinase. Last modified on 27/03/2019. Accessed on 21/10/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=3073.