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Plasmodium falciparum phosphatidylinositol 3-kinase

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Target id: 3073

Nomenclature: Plasmodium falciparum phosphatidylinositol 3-kinase

Abbreviated Name: PfPI3K

Family: Kinases (Plasmodium spp.)

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Plasmodium falciparum 3D7 - 2133 PI3K phosphatidylinositol 3-kinase
Previous and Unofficial Names Click here for help
PfVPS34
Database Links Click here for help
PlasmoDB
UniProtKB
Malaria Pharmacology Comments
P. falciparum phosphatidylinositol 3-kinase (PfPI3K) is the only PI3K that has been identified in the parasite's genome, with sequence analysis and domain organization suggesting that it may be closest to class III PI3Ks, such as VPS34 [1]. The same study found that PfPI3K is involved in endocytosis from the host and trafficking of haemoglobin in the parasite, with inhibition of PI3K causing accumulation of uncatabolized haemoglobin.
The PI3K inhibitors wortmannin and LY 294002 have been shown to be effective against PfPI3K [1] but selectivity at the Plasmodium target is likely to be a key issue.

References

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1. Vaid A, Ranjan R, Smythe WA, Hoppe HC, Sharma P. (2010) PfPI3K, a phosphatidylinositol-3 kinase from Plasmodium falciparum, is exported to the host erythrocyte and is involved in hemoglobin trafficking. Blood, 115 (12): 2500-7. [PMID:20093402]

How to cite this page

Kinases (Plasmodium spp.): Plasmodium falciparum phosphatidylinositol 3-kinase. Last modified on 25/02/2021. Accessed on 07/05/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=3073.