Plasmodium falciparum serine hydroxymethyltransferase | Antimalarial targets | IUPHAR/MMV Guide to MALARIA PHARMACOLOGY

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Plasmodium falciparum serine hydroxymethyltransferase

Target id: 3066

Nomenclature: Plasmodium falciparum serine hydroxymethyltransferase

Abbreviated Name: PfSHMT

Family: Antimalarial targets

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Plasmodium falciparum 3D7 - 442 SHMT serine hydroxymethyltransferase
Database Links
UniProtKB
Selected 3D Structures
Image of receptor 3D structure from RCSB PDB
Description:  Crystal structure of serine hydroxymethyltransferase with covalently bound PLP Schiff-base from Plasmodium falciparum
PDB Id:  4O6Z
Resolution:  2.98Å
Species:  Plasmodium falciparum
References:  1
Malaria Pharmacology Comments
The P. falciparum enzyme serine hydroxymethyltransferase (PfSHMT) is involved in folate recycling. It is part of the deoxythymidylate synthesis cycle where dTMP is biosynthesized and the oxidized folate compounds generated are recycled by synchronized cooperation of PfSHMT and bifunctional PfDHFR-TS. PfSHMT has recently been validated as a chemically tractable antimalarial drug target [2].

References

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1. Chitnumsub P, Ittarat W, Jaruwat A, Noytanom K, Amornwatcharapong W, Pornthanakasem W, Chaiyen P, Yuthavong Y, Leartsakulpanich U. (2014) The structure of Plasmodium falciparum serine hydroxymethyltransferase reveals a novel redox switch that regulates its activities. Acta Crystallogr. D Biol. Crystallogr., 70 (Pt 6): 1517-27. [PMID:24914963]

2. Schwertz G, Witschel MC, Rottmann M, Leartsakulpanich U, Chitnumsub P, Jaruwat A, Amornwatcharapong W, Ittarat W, Schäfer A, Aponte RA et al.. (2018) Potent Inhibitors of Plasmodial Serine Hydroxymethyltransferase (SHMT) Featuring a Spirocyclic Scaffold. ChemMedChem, 13 (9): 931-943. [PMID:29655285]

How to cite this page

Antimalarial targets: Plasmodium falciparum serine hydroxymethyltransferase. Last modified on 27/03/2019. Accessed on 21/10/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=3066.