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poly (ADP-ribose) polymerase 3

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Target id: 2864

Nomenclature: poly (ADP-ribose) polymerase 3

Abbreviated Name: PARP3

Family: Poly ADP-ribose polymerases

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 533 3p21.2 PARP3 poly(ADP-ribose) polymerase family member 3
Mouse - 528 9 F1 Parp3 poly (ADP-ribose) polymerase family, member 3
Rat - 526 8q32 Parp3 poly (ADP-ribose) polymerase family, member 3
Previous and Unofficial Names Click here for help
poly (ADP-ribose) polymerase family, member 3 | poly (ADP-ribose) polymerase family | ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)-like 3 | ADPRTL3 | IRT1 | pADPRT-3 | poly(ADP-ribose) synthetase-3
Database Links Click here for help
Alphafold
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
SynPHARM
UniProtKB
Wikipedia

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
ME0328 Small molecule or natural product Primary target of this compound Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 6.1 pIC50 1
pIC50 6.1 (IC50 9x10-7 M) [1]
Immuno Process Associations
Immuno Process:  B cell (activation)
GO Annotations:  Associated to 1 GO processes
GO:0045829 negative regulation of isotype switching ISS
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 1 GO processes
GO:0045829 negative regulation of isotype switching ISS
Immuno Process:  Immune regulation
GO Annotations:  Associated to 1 GO processes
GO:0045829 negative regulation of isotype switching ISS
Immuno Process:  Immune system development
GO Annotations:  Associated to 1 GO processes
GO:0045829 negative regulation of isotype switching ISS
Immuno Process:  Inflammation
GO Annotations:  Associated to 1 GO processes
GO:0045829 negative regulation of isotype switching ISS
Immuno Process:  T cell (activation)
GO Annotations:  Associated to 1 GO processes
GO:0045829 negative regulation of isotype switching ISS

References

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1. Lindgren AE, Karlberg T, Ekblad T, Spjut S, Thorsell AG, Andersson CD, Nhan TT, Hellsten V, Weigelt J, Linusson A et al.. (2013) Chemical probes to study ADP-ribosylation: synthesis and biochemical evaluation of inhibitors of the human ADP-ribosyltransferase ARTD3/PARP3. J Med Chem, 56 (23): 9556-68. [PMID:24188023]

How to cite this page

Poly ADP-ribose polymerases: poly (ADP-ribose) polymerase 3. Last modified on 28/11/2018. Accessed on 26/09/2022. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=2864.