Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	189	11p15.5	HRAS	HRas proto-oncogene, GTPase
Mouse	-	189	7 86.48 cM	Hras	Harvey rat sarcoma virus oncogene
Rat	-	189	1q41	Hras	HRas proto-oncogene, GTPase
Gene and Protein Information Comments
Three isoforms have been identified for human HRAS. Isoforms 1 and 3 are both 189 amino acids long, but isoform 2 (NP_789765) is shorter (170 amino acids) and has a distinct C-terminus. The mouse protein also has three isoforms, 1 and 2 are 189 amino acids long and isoform 2 (NP_001123916) is 188 amino acids. Two transcripts have been identified in the rat, both produce identical proteins of 189 amino acids.

Previous and Unofficial Names

HRAS1 | transforming protein p21 | Harvey rat sarcoma viral oncogene homolog | Harvey rat sarcoma virus oncogene | HRas proto-oncogene, GTPase | HRas proto-oncogene

Database Links
Alphafold	P01112 (Hs), Q61411 (Mm), P20171 (Rn)
ChEMBL Target	CHEMBL2167 (Hs)
Ensembl Gene	ENSG00000174775 (Hs), ENSMUSG00000025499 (Mm), ENSRNOG00000016611 (Rn)
Entrez Gene	3265 (Hs), 15461 (Mm), 293621 (Rn)
Human Protein Atlas	ENSG00000174775 (Hs)
KEGG Gene	hsa:3265 (Hs), mmu:15461 (Mm), rno:293621 (Rn)
OMIM	190020 (Hs)
Pharos	P01112 (Hs)
RefSeq Nucleotide	NM_005343 (Hs), NM_176795 (Hs), NM_001130442 (Hs), NM_001130443 (Mm), NM_001130444 (Mm), NM_008284 (Mm), NM_001098241 (Rn), NM_001130441 (Rn)
RefSeq Protein	NP_001123914 (Hs), NP_789765 (Hs), NP_005334 (Hs), NP_001123915 (Mm), NP_032310 (Mm), NP_001123916.1 (Mm), NP_001091711 (Rn), NP_001123913 (Rn)
UniProtKB	P01112 (Hs), Q61411 (Mm), P20171 (Rn)
Wikipedia	HRAS (Hs)

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference lonafarnib Hs Inhibition 8.7 pIC50 1 ⤷ pIC50 8.7 (IC50 1.9x10-9 M) [1] Description: Measuring inhibition of farnesylation of HRAS by human farnesyltransferase

Immuno Process Associations

Immuno Process:  Inflammation

Immuno Process:  Immune regulation

Immuno Process:  Cellular signalling

Immuno Process:  Antigen presentation

Immuno Process:  T cell (activation)

Immuno Process:  B cell (activation)

Immuno Process:  Cytokine production & signalling

Clinically-Relevant Mutations and Pathophysiology
Disease:  Bladder cancer Disease Ontology: DOID:11054 OMIM: 109800
Disease:  Costello syndrome; CSTLO Disease Ontology: DOID:0050469 OMIM: 218040 Orphanet: ORPHA3071
Disease:  Nevus, epidermal Disease Ontology: DOID:0050532 OMIM: 162900
Disease:  Phakomatosis pigmentokeratotica Orphanet: ORPHA2874
Disease:  Schimmelpenning-Feuerstein-Mims syndrome; SFM Synonyms: Linear nevus sebaceus syndrome [Orphanet: ORPHA2612] OMIM: 163200 Orphanet: ORPHA2612
Disease:  Thyroid carcinoma, follicular; FTC Synonyms: Differentiated thyroid carcinoma [Orphanet: ORPHA146] Follicular thyroid carcinoma [Disease Ontology: DOID:3962] Disease Ontology: DOID:3962 OMIM: 188470 Orphanet: ORPHA146