Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	1	329	3q13.33	CD86	CD86 molecule
Mouse	1	309	16 25.72 cM	Cd86	CD86 antigen
Rat	-	313	11q22	Cd86	CD86 molecule

Previous and Unofficial Names

CD86 antigen

Database Links
Alphafold	P42081 (Hs), P42082 (Mm)
CATH/Gene3D	2.60.40.10
ChEMBL Target	CHEMBL2364156 (Hs)
DrugBank Target	P42081 (Hs)
Ensembl Gene	ENSG00000114013 (Hs), ENSMUSG00000022901 (Mm), ENSRNOG00000038835 (Rn)
Entrez Gene	942 (Hs), 12524 (Mm), 56822 (Rn)
Human Protein Atlas	ENSG00000114013 (Hs)
KEGG Gene	hsa:942 (Hs), mmu:12524 (Mm), rno:56822 (Rn)
OMIM	601020 (Hs)
Pharos	P42081 (Hs)
RefSeq Nucleotide	NM_175862 (Hs), NM_019388 (Mm), NM_020081 (Rn)
RefSeq Protein	NP_787058 (Hs), NP_062261 (Mm), NP_064466 (Rn)
UniProtKB	P42081 (Hs), P42082 (Mm)
Wikipedia	CD86 (Hs)

Immunopharmacology Comments

CD86 (B7-2) is a type I membrane immunoglobulin. It is expressed on antigen-presenting cells and in association with CD80 provides the costimulatory signal necessary for T cell activation and survival. CD86 interacts with CD28 or CTLA-4 on T cells. It is the interaction with CTLA-4 that is targeted by the approved immunosuppresive drugs abatacept and belatacept.

Cell Type Associations

Immuno Cell Type:  Macrophages & monocytes Cell Ontology Term:   macrophage (CL:0000235) Comment:  CD86 is expressed on antigen-presenting cells.

Immuno Cell Type:  Dendritic cells Cell Ontology Term:   dendritic cell (CL:0000451)

Immuno Cell Type:  B cells Cell Ontology Term:   B cell (CL:0000236)

Immuno Process Associations

Immuno Process:  Inflammation GO Annotations:  Associated to 1 GO processes GO:0045630 positive regulation of T-helper 2 cell differentiation NAS

Immuno Process:  T cell (activation) GO Annotations:  Associated to 5 GO processes GO:0031295 T cell costimulation IBA GO:0042102 positive regulation of T cell proliferation IBA GO:0042130 negative regulation of T cell proliferation IBA GO:0045630 positive regulation of T-helper 2 cell differentiation NAS click arrow to show/hide IEA associations GO:0002250 adaptive immune response IEA

Immuno Process:  Immune regulation GO Annotations:  Associated to 5 GO processes GO:0002639 positive regulation of immunoglobulin production ISS GO:0031295 T cell costimulation IBA GO:0042102 positive regulation of T cell proliferation IBA GO:0042130 negative regulation of T cell proliferation IBA GO:0045630 positive regulation of T-helper 2 cell differentiation NAS

Immuno Process:  Immune system development GO Annotations:  Associated to 1 GO processes GO:0045630 positive regulation of T-helper 2 cell differentiation NAS

Immuno Process:  Cytokine production & signalling GO Annotations:  Associated to 3 GO processes GO:0032743 positive regulation of interleukin-2 production NAS GO:0032753 positive regulation of interleukin-4 production NAS GO:0032761 positive regulation of lymphotoxin A production NAS

Immuno Process:  Chemotaxis & migration GO Annotations:  Associated to 4 GO processes GO:0031295 T cell costimulation IBA GO:0042102 positive regulation of T cell proliferation IBA GO:0042130 negative regulation of T cell proliferation IBA GO:0045630 positive regulation of T-helper 2 cell differentiation NAS

Immuno Process:  Cellular signalling GO Annotations:  Associated to 5 GO processes GO:0031295 T cell costimulation IBA GO:0042102 positive regulation of T cell proliferation IBA GO:0042113 B cell activation ISS GO:0042130 negative regulation of T cell proliferation IBA GO:0045630 positive regulation of T-helper 2 cell differentiation NAS

Immuno Process:  Barrier integrity GO Annotations:  Associated to 1 GO processes, IEA only click arrow to show/hide IEA associations GO:0001618 virus receptor activity IEA

Immuno Process:  B cell (activation) GO Annotations:  Associated to 2 GO processes, IEA only GO:0042113 B cell activation ISS click arrow to show/hide IEA associations GO:0002250 adaptive immune response IEA

Immuno Disease Associations

Disease Name:  Rheumatoid arthritis Disease Synonyms:  no synonynms Comment:  CD86 is a primary target of the ligand abatacept, which is clinically approved for the treatment of rheumatoid arthritis. Disease X-refs:  Disease Ontology: DOID:7148 OMIM: 180300 References:  3

Disease Name:  Graft versus host disease Disease Synonyms:  no synonynms Comment:  CD86 is a primary target of the approved anti-rejection drug belatacept.

General Comments
This protein contains an immunoglobulin (Ig)-like domain that resembles the antibody variable domain, that has been coined the 'V-set domain'. The genes for all human V-set domain containing proteins are listed in HGNC gene group 590.