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Gene and Protein Information | ||||||
Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | - | 2224 | 1q24.2 | F5 | coagulation factor V | |
Mouse | - | 2183 | 1 71.46 cM | F5 | coagulation factor V | |
Rat | - | 1942 | 13q22 | F5 | coagulation factor V |
Previous and Unofficial Names |
coagulation factor V (proaccelerin, labile factor) |
Database Links | |
Alphafold | P12259 (Hs), O88783 (Mm) |
CATH/Gene3D | 2.60.120.260, 2.60.40.420 |
ChEMBL Target | CHEMBL3618 (Hs) |
DrugBank Target | P12259 (Hs) |
Ensembl Gene | ENSG00000198734 (Hs), ENSMUSG00000026579 (Mm), ENSRNOG00000057855 (Rn) |
Entrez Gene | 2153 (Hs), 14067 (Mm), 304929 (Rn) |
Human Protein Atlas | ENSG00000198734 (Hs) |
KEGG Gene | hsa:2153 (Hs), mmu:14067 (Mm), rno:304929 (Rn) |
OMIM | 612309 (Hs) |
Orphanet | ORPHA121673 (Hs) |
Pharos | P12259 (Hs) |
RefSeq Nucleotide | NM_000130 (Hs), NM_007976 (Mm), NM_001047878 (Rn) |
RefSeq Protein | NP_000121 (Hs), NP_032002 (Mm) |
UniProtKB | P12259 (Hs), O88783 (Mm) |
Wikipedia | F5 (Hs) |
Selected 3D Structures | |||||||||||
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Download all structure-activity data for this target as a CSV file
Inhibitors | |||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | Click column headers to sort | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Phenotypes, Alleles and Disease Models | Mouse data from MGI | ||||||||||||||||||||||||||||||||||||
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Clinically-Relevant Mutations and Pathophysiology | ||||||||||||
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1. Kanji S, Devlin JW, Piekos KA, Racine E. (2001) Recombinant human activated protein C, drotrecogin alfa (activated): a novel therapy for severe sepsis. Pharmacotherapy, 21 (11): 1389-402. [PMID:11714212]
2. Kapur S, Kupfer Y, Tessler S. (2001) Recombinant human activated protein C for severe sepsis. N Engl J Med, 345 (3): 219-20; author reply 220-1. [PMID:11463021]
3. Macedo-Ribeiro S, Bode W, Huber R, Quinn-Allen MA, Kim SW, Ortel TL, Bourenkov GP, Bartunik HD, Stubbs MT, Kane WH et al.. (1999) Crystal structures of the membrane-binding C2 domain of human coagulation factor V. Nature, 402 (6760): 434-9. [PMID:10586886]